1 Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montreal, H4B 1R6, Quebec, Canada. letian.song@concordia.ca.
2 Centre for Structural and Functional Genomics, Concordia University, 7141 Sherbrooke Street West, Montreal, H4B 1R6, Quebec, Canada.
3 Centre for Structural and Functional Genomics, Concordia University, Montreal, QC, Canada.

Phylogenetic Analysis of Protein Family.



Methods Mol Biol. 2018;1775:267-275



Authors: Song L, Wu S, Tsang A



Abstract

With the number of sequenced genomes increasing rapidly, it is impractical to perform functional and structural analyses on all individual proteins. Phylogenetic analysis employs a combination of molecular and statistical approaches to infer or estimate relationships among individuals. It provides a credible method to explore the relationship between sequence similarity and function of proteins belonging to the same family. This chapter describes a standardized framework of phylogenetic analysis to study large protein families. Bioinformatic approaches and online tools used in phylogenetic analyses are presented.



PMID: 29876824 [PubMed - indexed for MEDLINE]