Author(s): McComb S; Arbabi-Ghahroudi M; Hay KA; Keller BA; Faulkes S; Rutherford M; Nguyen T; Shepherd A; Wu C; Marcil A; Aubry A; Hussack G; Pinto DM; Ryan S; Raphael S; van Faassen H; Zafer A; Zhu Q; Maclean S; Chattopadhyay A; Gurnani K; Gilber ...

Chimeric antigen receptor (CAR) T cell therapies targeting B cell-restricted antigens CD19, CD20, or CD22 can produce potent clinical responses for some B cell malignancies, but relapse remains common. Camelid single-domain antibodies (sdAbs or nanobodies) are smaller, simpler, and easier to reco ...

Article GUID: 38596311

Author(s): Sharmeen N; Law C; Wu C;

In response to pheromone, many proteins localize on the plasma membrane of yeast cell to reform it into a polarized shmoo structure. The adaptor protein Ste50p, known as a pheromone signal enhancer critical for shmoo polarization, has never been explored systematically for its localization and function in the polarization process. Time-lapse single-cell i ...

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Author(s): Camilus NS; Lucas S; Wu C; Naccache R; Martic S;

Background: Globally, a number of individuals who live with Alzheimer's disease (AD), an incurable and debilitating disease, is increasing. Tau protein has a structural role, maintains integrity of microtubules and is one of the underlying causes of the tauopathies [1]. It is unfolded and highly soluble under physiological conditions. However, tau pro ...

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Author(s): Sharmeen N, Sulea T, Whiteway M, Wu C

Mol Biol Cell. 2019 03 15;30(6):794-807 Authors: Sharmeen N, Sulea T, Whiteway M, Wu C

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Author(s): Wu C, De Visscher A, Gates ID

J Phys Chem B. 2018 07 05;122(26):6771-6780 Authors: Wu C, De Visscher A, Gates ID

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