Author(s): Kendzerska T; Mallick R; Li W; Robillard R; Taler V; Webber C; Saymeh M; Dang-Vu TT; Tanuseputro P; Fiedorowicz JG;
Importance: Despite plausible mechanisms linking obstructive sleep apnea (OSA) and mental health conditions, prospective studies from representative samples are needed to estimate temporal associations between OSA and mental health conditions during aging. Objective: To evaluate whether high ris ...
Article GUID: 41632160
Author(s): Paez A; Dogaheh SB; Gillman SO; Carnes A; Dakterzada F; Barbe F; Piñol-Ripoll G; Dang-Vu TT;
Background: Sleep is essential for brain-health, including clearance of ß-amyloid (Aß), tau, and otherpromising diagnostic markers of neurodegeneration and progression in Alzheimer's Disease (AD): cerebrospinal fluid neurofilament-light chain (NfL), neurogranin-36 (NG-36), an ...
Article GUID: 41512123
Author(s): Paez A; Piñol-Ripoll G; Dogaheh SB; Gillman SO; Dakterzada F; Carnes A; Barbe F; Dang-Vu TT;
Background: Cerebrospinal fluid (CSF) orexin levels are higher in MCI and AD and associated with sleep deterioration, increasing risk of cognitive decline and Alzheimer's disease (AD) progression. Orexin-A is a key sleep-wake cycle regulator. Dual orexin receptor antagonists ...
Article GUID: 41512277
Author(s): Cunningham NP; Tremblay-Mercier J; Baril AA; Dang-Vu TT; Lim A; Geddes MR; Badawy M; Poirier J; Ducharme S; Villeneuve S;
Background: Poor sleep is a modifiable factor associated with the development and progression of Alzheimer's Disease (AD). Pharmacological treatments and Cognitive Behavioural Therapy for Insomnia (CBT-I) which promote sleep have the potential to improve AD risk profile. In addition, prior re ...
Article GUID: 41450269
Author(s): Gurve D; Centen AP; Slack PJ; Dang-Vu TT; Belleville S; Anderson ND; Montero-Odasso M; Nygaard HB; Chertkow H; Feldman HH; Brewster PWH; Lim A;
Background: Older adults experience considerable day-to-day variability in cognitive function. We aimed to test the hypothesis that this is in part related to sleep, and determine which EEG sleep features are most important in supporting day to day cognitive resilience. Method: We analyzed data ...
Article GUID: 41434309
Author(s): Barbaux L; Cross NE; Perrault AA; Es-Sounni M; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Tannenbaum C; Guimond A; Grenier S; Gouin JP; Dang-Vu TT;
Objectives: Our objective was to assess the effect of cognitive-behavioral therapy for insomnia (CBTi) on subjective and objective sleep quality (including sleep spindles) and cognition during a sedative-hypnotics withdrawal program in older adults with insomnia disorder.
Article GUID: 41092866
Author(s): Perrault AA; Kebets V; Kuek NMY; Cross NE; Tesfaye R; Pomares FB; Li J; Chee MWL; Dang-Vu TT; Yeo BTT;
Sleep is essential for optimal functioning and health. Interconnected to multiple biological, psychological, and socio-environmental factors (i.e., biopsychosocial factors), the multidimensional nature of sleep is rarely capitalized on in research. Here, we deployed a data-driven approach to iden ...
Article GUID: 41056215
Author(s): Vézina-Im LA; Morin CM; Chen S; Ivers H; Carney CE; Chaput JP; Dang-Vu TT; Davidson JR; Robillard R;
Objectives: To evaluate whether bedtime screen use is associated with sleep health and if this association varies by biological sex, age, and income among adults in Canada. Methods: Data were collected through a national stratified random population-based phone interview on sleep health among ad ...
Article GUID: 40713469
Author(s): Ferland MC; Wang R; Therrien-Blanchet JM; Remahi S; Côté S; Fréchette AJ; Dang-Vu TT; Liu H; Lepage JF; Théoret H;
Lorazepam is a fast-acting benzodiazepine that is widely used to manage anxiety symptoms through modulation of GABAergic activity. Despite being one of the most prescribed benzodiazepines, the effects of a single dose of lorazepam on brain functional connectivity at rest is not known. In this pla ...
Article GUID: 40646404
Author(s): Barbaux L; Perrault AA; Cross NE; Weiner OM; Es-Sounni M; Pomares FB; Tarelli L; McCarthy M; Maltezos A; Smith D; Gong K; O' Byrne J; Yue V; Desrosiers C; Clerc D; Andriamampionona F; Lussier D; Gilbert S; Tannenbaum C; Gouin JP; Da ...
Study objectives: Insomnia in older adults is associated with widespread benzodiazepine (BZD) and benzodiazepine receptor agonist (BZRA) use, despite evidence that chronic use disrupts sleep regulation and cognition. Little is known about BZD/BZRA effects on NREM slow oscillations (SO), spindles ...
Article GUID: 40570297
Author(s): Chen SJ; Ivers H; Dang-Vu TT; Shapiro CM; Carney CE; Robillard R; Morin CM;
Introduction: Insomnia is a prevalent yet under-characterized disorder, particularly regarding the heterogeneity of patients and their associated responses to different treatment modalities. This often leads to suboptimal management. There is a need to consider personalized approaches tailored to the characteristics of insomnia phenotypes with regard to o ...
Article GUID: 40346496
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