Author(s): Turner L; Wanasinghe AI; Brunori P; Santosa S;

In individuals with obesity, the onset of chronic comorbidities coincides with the excessive accumulation of adipose tissue in various tissue beds. As obesity progresses, adipose tissue becomes increasingly dysfunctional causing chronic low-grade inflammation. Indeed, adipose tissue inflammation, which partially stems from macrophage infiltration and expr ...

Article GUID: 40533358

Author(s): Turner L; Gauthier MF; Lafortune A; Tchernof A; Santosa S;

Background: The timing of obesity onset and age have been shown to affect the risk of obesity-related comorbidities, although the impact of each of these factors on markers of adipose tissue function remains unclear. Objective: The aim of this study was to determine whether differences in regional adipose tissue characteristics vary with age and age of o ...

Article GUID: 35927468

Author(s): Turner L; Santosa S;

With increasing adiposity in obesity, adipose tissue macrophages contribute to adipose tissue malfunction and increased circulating proinflammatory cytokines. The chronic low-grade inflammation that occurs in obesity ultimately gives rise to a state of metainflammation that increases the risk of metabolic disease. To date, only lifestyle and surgical inte ...

Article GUID: 33979430