1 Sezione di Igiene, Istituto di Sanità Pubblica, Università Cattolica del Sacro Cuore.
2 Department of Health, Kinesiology, and Applied Physiology, Concordia University, Montreal.
3 Montreal Behavioural Medicine Centre, CIUSSS du Nord-de-l'Île-de-Montréal, Montreal, Quebec, Canada.
4 Dipartimento di Chirurgia, Università Cattolica del Sacro Cuore.
5 Department of Woman and Child Health and Public Health - Public Health Area, Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italia.
6 Harbin Medical University, Harbin, China.
7 School of Epidemiology, Public Health and Preventive Medicine, University of Ottawa, Ottawa, Ontario, Canada.
8 Department of Epidemiology, UCLA Fielding School of Public Health and Jonsson Comprehensive Cancer Center, Los Angeles, California, USA.
9 Department of Clinical Sciences and Community Health, University of Milan, Milan.
10 Cancer Risk Factors and Life-Style Epidemiology Unit, Institute for Cancer Research, Prevention and Clinical Network, ISPRO, Florence, Italy.
11 Medical Informatics Center, Peking University, Peking, China.
12 Departamento de Ciências da Saúde Pública e Forenses e Educação Médica, Faculdade de Medicina da Universidade do Porto, Al. Prof. Hernâni Monteiro.
13 EPIUnit - Instituto de Saúde Pública, Universidade do Porto, Porto, Portugal.
14 Digestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
15 Department of Public Health Sciences, Tobacco Center of Regulatory Science, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA.
16 Department of Epidemiology and Prevention, Russian N.N. Blokhin Cancer Research Center, Moscow, Russia.
17 Epidemiology Section, Public Health Division, Department of Health of Madrid, Madrid.
18 CIBER of Epidemiology and Public Health (CIBERESP), Madrid.
19 The Research Group in Gene - Environment and Health Interactions (GIIGAS), Leon (Spain), Biomedicine Institute (IBIOMED), University of León.
20 Department of Public Health, Miguel Hernandez University, FISABIO-ISABIAL, Campus San Juan, Alicante, Spain.
21 Department of Agricultural, Food and Nutritional Sciences, University of Alberta, Edmonton, Alberta, Canada.
22 Nutritional Epidemiology Group, Centre for Epidemiology and Biostatistics, University of Leeds, Leeds, UK.
23 Department of Biomedical and Clinical Sciences, University of Milan, Milan, Italy.
24 Digestive Disease Research Center, Ardabil University of Medical Sciences, Ardabil, Iran.
25 Department of Epidemiology and Environmental Health, School of Public Health and Health Professions, University at Buffalo, Buffalo.
26 Department of Medicine, Memorial Sloan Kettering Cancer Centre, New York, New York, USA.
27 Department of Public and Community Health, School of Health Sciences, University of West Attica, Athens (Greece).
28 Department of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Athens, Greece.
29 Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

Adult height and risk of gastric cancer: a pooled analysis within the Stomach cancer Pooling Project.

Eur J Cancer Prev. 2020 Sep 10; :

Authors: Giraldi L, Stojanovic J, Arzani D, Persiani R, Hu J, Johnson KC, Zhang ZF, Ferraroni M, Palli D, Yu GP, La Vecchia C, Pelucchi C, Lunet N, Ferro A, Malekzadeh R, Muscat J, Zaridze D, Maximovich D, Aragones N, Martin V, Vioque J, Navarrete-Munoz EM, Pakseresht M, Negri E, Rota M, Pourfarzi F, Mu L, Kurtz RC, Lagiou A, Lagiou P, Pastorino R, Boccia S

Abstract

BACKGROUND: The association between height and risk of gastric cancer has been studied in several epidemiological studies with contrasting results. The aim of this study is to examine the association between adult height and gastric cancer within a large pooled analysis of case-control studies members of the Stomach cancer Pooling (StoP) Project consortium.

METHODS: Data from 18 studies members of the StoP consortium were collected and analyzed. A multivariable logistic regression model was used to estimate the study-specific odds ratios (ORs) and 95% confidence intervals (CIs) for the association between 10-cm increase in height and risk of gastric cancer. Age, sex, tobacco smoking, alcohol consumption, social class, geographical area and Helicobacter pylori (H. pylori) status were included in the regression model. Resulting estimates were then pooled with random-effect model. Analyses were conducted overall and in strata of selected variables.

RESULTS: A total of 7562 cases and 19 033 controls were included in the analysis. The pooled OR was 0.96 (95% CI 0.87-1.05). A sensitivity analysis was performed restricting the results to the studies with information on H. pylori status, resulting in an OR of 0.97 (95% CI 0.79-1.20).

CONCLUSION: Our study does not support a strong and consistent association between adult height and gastric cancer.

PMID: 32925512 [PubMed - as supplied by publisher]