Author(s): Carter F; Cossette MP; Trujillo-Pisanty I; Pallikaras V; Breton YA; Conover K; Caplan J; Solis P; Voisard J; Yaksich A; Shizgal P; ...
Phasic dopamine activity is believed to both encode reward-prediction errors (RPEs) and to cause the adaptations that these errors engender. If so, a rat working for optogenetic stimulation of dopa ...
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Major depressive disorder is a leading cause of disability and suicide worldwide. Consecutive rounds of conventional interventions are ineffective in a significant sub-group of patients whose disorder is classified as treatment-resistant depression. Signifi ...
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Author(s): Pallikaras V; Shizgal P;
Deep-brain stimulation of the medial forebrain bundle (MFB) can provide effective, enduring relief of treatment-resistant depression. Panksepp provided an explanatory framework: the MFB constitutes the core of the neural circuitry subserving the anticipatio ...
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Author(s): Pallikaras V; Carter F; Velazquez-Martinez DN; Arvanitogiannis A; Shizgal P;
Optogenetic experiments reveal functional roles of specific neurons. However, functional inferences have been limited by widespread adoption of a restricted set of stimulation parameters. Broader exploration of the parameter space can deepen insight into th ...
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Eur J Neurosci. 2019 Jul 27;: Authors: Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumro ...
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PLoS One. 2017;12(8):e0182120 Authors: Solomon RB, Conover K, Shizgal P
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Neurosci Lett. 2018 02 05;665:29-32 Authors: Shams WM, Cossette MP, Shizgal P, Brake WG
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