Author(s): Carter F; Cossette MP; Trujillo-Pisanty I; Pallikaras V; Breton YA; Conover K; Caplan J; Solis P; Voisard J; Yaksich A; Shizgal P;
Phasic dopamine activity is believed to both encode reward-prediction errors (RPEs) and to cause the adaptations that these errors engender. If so, a rat working for optogenetic stimulation of dopamine neurons will repeatedly update its policy and/or action values, thus iteratively increasing its ...
Article GUID: 38039083
Author(s): Pallikaras V; Shizgal P;
Major depressive disorder is a leading cause of disability and suicide worldwide. Consecutive rounds of conventional interventions are ineffective in a significant sub-group of patients whose disorder is classified as treatment-resistant depression. Significant progress in managing this severe form of depression has been achieved through the use of deep b ...
Article GUID: 36009115
Author(s): Pallikaras V; Shizgal P;
Deep-brain stimulation of the medial forebrain bundle (MFB) can provide effective, enduring relief of treatment-resistant depression. Panksepp provided an explanatory framework: the MFB constitutes the core of the neural circuitry subserving the anticipation and pursuit of rewards: the "SEEKING" system. On that view, the SEEKING system is hypoactive in de ...
Article GUID: 35431828
Author(s): Pallikaras V; Carter F; Velazquez-Martinez DN; Arvanitogiannis A; Shizgal P;
Optogenetic experiments reveal functional roles of specific neurons. However, functional inferences have been limited by widespread adoption of a restricted set of stimulation parameters. Broader exploration of the parameter space can deepen insight into the mapping between selective neural activity and behavior. In this way, characteristics of the activa ...
Article GUID: 34864162
Author(s): Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P
PLoS One. 2020;15(6):e0226722 Authors: Trujillo-Pisanty I, Conover K, Solis P, Palacios D, Shizgal P
Article GUID: 32502210
Author(s): Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumrouyan RA, Patel S, Lorenc V, Gagne C, El Oufi K, Shizgal P, Brake WG
Eur J Neurosci. 2019 Jul 27;: Authors: Evangelista C, Hantson A, Shams WM, Almey A, Pileggi M, Voisard JR, Boulos V, Al-Qadri Y, Gonzalez Cautela BV, Zhou FX, Duchemin J, Habrich A, Tito N, Koumrouyan RA, Patel S, Lorenc V, Gagne C, El Oufi K, Shizgal P, Brake WG
Article GUID: 31350860
Author(s): Ahilan S, Solomon RB, Breton YA, Conover K, Niyogi RK, Shizgal P, Dayan P
PLoS Comput Biol. 2019 Jun 24;15(6):e1007093 Authors: Ahilan S, Solomon RB, Breton YA, Conover K, Niyogi RK, Shizgal P, Dayan P
Article GUID: 31233559
Author(s): Hernandez G, Cossette MP, Shizgal P, Rompré PP
Front Behav Neurosci. 2016;10:161 Authors: Hernandez G, Cossette MP, Shizgal P, Rompré PP
Article GUID: 27616984
Author(s): Solomon RB, Conover K, Shizgal P
PLoS One. 2017;12(8):e0182120 Authors: Solomon RB, Conover K, Shizgal P
Article GUID: 28841663
Author(s): Shams WM, Cossette MP, Shizgal P, Brake WG
Neurosci Lett. 2018 02 05;665:29-32 Authors: Shams WM, Cossette MP, Shizgal P, Brake WG
Article GUID: 29175028
Author(s): Niyogi RK, Shizgal P, Dayan P
PLoS Comput Biol. 2014 Dec;10(12):e1003894 Authors: Niyogi RK, Shizgal P, Dayan P
Article GUID: 25474151
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