1 Department of Electrical and Computer Engineering, North South University, Bashundhara, Dhaka, 1229, Bangladesh. Electronic address: deponker.sarker@northsouth.edu.
2 Department of Electrical and Computer Engineering, North South University, Bashundhara, Dhaka, 1229, Bangladesh; Texas Tech University, Lubbock, TX, United States of America. Electronic address: mashfiq.rizvee@northsouth.edu.
3 Department of Electrical and Computer Engineering, North South University, Bashundhara, Dhaka, 1229, Bangladesh. Electronic address: aimon.rahman@northsouth.edu.
4 Concordia University, Montreal, QC, Canada. Electronic address: hasibzunair@gmail.com.
5 Department of Computer Science and Engineering, Bangladesh University of Engineering and Technology, ECE Building, West Palasi, Dhaka 1205, Bangladesh. Electronic address: msrahman@cse.buet.ac.bd.
6 Department of Electrical and Computer Engineering, North South Un

Uncontrolled proliferation of B-lymphoblast cells is a common characterization of Acute Lymphoblastic Leukemia (ALL). B-lymphoblasts are found in large numbers in peripheral blood in malignant cases. Early detection of the cell in bone marrow is essential as the disease progresses rapidly if left untreated. However, automated classification of the cell is challenging, owing to its fine-grained variability with B-lymphoid precursor cells and imbalanced data points. Deep learning algorithms demonstrate potential for such fine-grained classification as well as suffer from the imbalanced class problem. In this paper, we explore different deep learning-based State-Of-The-Art (SOTA) approaches to tackle imbalanced classification problems. Our experiment includes input, GAN (Generative Adversarial Networks), and loss-based methods to mitigate the issue of imbalanced class on the challenging C-NMC and ALLIDB-2 dataset for leukemia detection. We have shown empirical evidence that loss-based methods outperform GAN-based and input-based methods in imbalanced classification scenarios.