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Chromosome-level genome assembly of a doubled haploid brook trout (Salvelinus fontinalis)

Author(s): Lecomte L; Ferchaud AL; Normandeau E; Mérot C; Langlois-Parisé I; Therrien JC; Bérubé P; Djambazian H; Nawarathna PM; Ragoussis J; Fraser D;

Brook trout (Salvelinus fontinalis) is a socioeconomically important fish species for fisheries, aquaculture and aquatic conservation. We produced a 2.5 Gb reference assembly by combining Hi-C chromosome conformation capture with high-coverage short- and long-read sequencing of a fully homozygous ...

Article GUID: 40130537


Evolution of chromosome-arm aberrations in breast cancer through genetic network rewiring

Author(s): Kuzmin E; Baker TM; Lesluyes T; Monlong J; Abe KT; Coelho PP; Schwartz M; Del Corpo J; Zou D; Morin G; Pacis A; Yang Y; Martinez C; Barber J; Kuasne H; Li R; Bourgey M; Fortier AM; Davison PG; Omeroglu A; Guiot MC; Morris Q; Kleinman CL; ...

The basal breast cancer subtype is enriched for triple-negative breast cancer (TNBC) and displays consistent large chromosomal deletions. Here, we characterize evolution and maintenance of chromosome 4p (chr4p) loss in basal breast cancer. Analysis of The Cancer Genome Atlas data shows recurrent ...

Article GUID: 38517886


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