Author(s): Maarouf-Mesli N; Fonseca JC; Harvey SM; Chauhan PS; Mulumba M; Ahsanullah None; Selka A; Meneksedag Erol D; Chemtob S; Ong H; Polyak F; Lubell WD;

Modern macrocyclic peptides feature unnatural elements that are used to improve the activity and pharmacokinetic properties. Chemistry beyond peptide synthesis must, however, be employed to introduce such elements. Notably, application of the copper-catalyzed aldehyde-alkyne-amine A3-reaction in ...

Article GUID: 42049622

Author(s): Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, ...

Article GUID: 33238462