Author(s): Paez A; Dogaheh SB; Gillman SO; Carnes A; Dakterzada F; Barbe F; Piñol-Ripoll G; Dang-Vu TT;

Background: Sleep is essential for brain-health, including clearance of ß-amyloid (Aß), tau, and otherpromising diagnostic markers of neurodegeneration and progression in Alzheimer's Disease (AD): cerebrospinal fluid neurofilament-light chain (NfL), neurogranin-36 (NG-36), an ...

Article GUID: 41512123

Author(s): Paez A; Piñol-Ripoll G; Dogaheh SB; Gillman SO; Dakterzada F; Carnes A; Barbe F; Dang-Vu TT;

Background: Cerebrospinal fluid (CSF) orexin levels are higher in MCI and AD and associated with sleep deterioration, increasing risk of cognitive decline and Alzheimer's disease (AD) progression. Orexin-A is a key sleep-wake cycle regulator. Dual orexin receptor antagonists ...

Article GUID: 41512277