Trans-regulatory variant network contributes to missing heritability
Authors: Pereira V, Kuzmin E
Affiliations
1 Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada.
2 Department of Biology, Concordia University, Montreal, Canada; Centre for Applied Synthetic Biology, Centre for Structural and Functional Genomics, Concordia University, Montreal, Canada; Department of Human Genetics, Rosalind & Morris Goodman Cancer Institute, McGill University, Montreal, Canada. Electronic address: elena.kuzmin@concordia.ca.
Description
In a recent Cell Genomics article, Tsouris et al.1 analyze the transcriptomes of a large diallel panel of hybrids from Saccharomyces cerevisiae natural isolates to study cis- and trans-regulatory changes underlying gene expression variation. Vanessa Pereira and Elena Kuzmin discuss the authors' findings and the wider context in missing heritability research in this preview.
Links
PubMed: https://pubmed.ncbi.nlm.nih.gov/38216282/
DOI: 10.1016/j.xgen.2023.100470
