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Prediction of depressive symptoms in young adults by polygenic score and childhood maltreatment: Results from a population-based birth cohort

Author(s): Scardera S; Geoffroy MC; Langevin R; Perret LC; Collin-Vézina D; Voronin I; Gouin JP; Meng X; Boivin M; Ouellet-Morin I;

Childhood maltreatment is linked with later depressive symptoms, but not every maltreated child will experience symptoms later in life. Therefore, we investigate whether genetic predisposition for depression (i.e., polygenic score for depression, PGSDEP) modifies the association between maltreatm ...

Article GUID: 39465601


Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis

Author(s): Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M;

Both common pain and anxiety problems are widespread, debilitating and often begin in childhood-adolescence. Twin studies indicate that this co-occurrence is likely due to shared elements of risk, rather than reciprocal causation. A joint genome-wide investigation and pathway/network-based analys ...

Article GUID: 37146008


The effects of walking in nature on negative and positive affect in adult psychiatric outpatients with major depressive disorder: A randomized-controlled study

Author(s): Watkins-Martin K; Bolani D; Richard-Devantoy S; Pennestri MH; Malboeuf-Hurtubise C; Philippe F; Guindon J; Gouin JP; Ouellet-Morin I; Geoffroy MC;

Background: While walking in nature has been shown to improve affect in adults from the community to a greater extent than walking in urban settings, it is unknown whether such benefits apply to individuals suffering from depression. Using a parallel group design, this randomized controlled trial ...

Article GUID: 36058362


Depression and anxiety symptoms in young adults before and during the COVID-19 pandemic: evidence from a Canadian population-based cohort

Author(s): Watkins-Martin K; Orri M; Pennestri MH; Castellanos-Ryan N; Larose S; Gouin JP; Ouellet-Morin I; Chadi N; Philippe F; Boivin M; Tremblay RE; Côté S; Geoffroy MC;

Background: Concerns have been raised that the COVID-19 pandemic could increase risk for adverse mental health outcomes, especially in young adults, a vulnerable age group. We investigated changes in depression and anxiety symptoms (overall and severe) from before to during the pandemic, as well ...

Article GUID: 34496901


Polygenic scores differentially predict developmental trajectories of subtypes of social withdrawal in childhood

Author(s): Morneau-Vaillancourt G; Andlauer TFM; Ouellet-Morin I; Paquin S; Brendgen MR; Vitaro F; Gouin JP; Séguin JR; Gagnon É; Cheesman R; Forget-Dubois N; Rouleau GA; Turecki G; Tremblay RE; Côté SM; Dionne G; Boivin M;

Background: Children who consistently withdraw from social situations face increased risk for later socioemotional difficulties. Twin studies indicate that genetic factors substantially account for the persistence of social withdrawal over time. However, the molecular genetic etiology of chronic ...

Article GUID: 34085288


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