Author(s): Samuel Olajide T; Oyerinde TO; Omotosho OI; Okeowo OM; Olajide OJ; Ijomone OM;
The existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the unders ...
Article GUID: 39364217
Author(s): Bamisi O; Oluwalabani AO; Arogundade TT; Olajide OJ;
Although there have been reports indicating that Datura Stramonium (D. stramonium) may induce anticholinergic and neuropsychiatry effects, the compound is still being used for recreational and medicinal purposes while ingestion during pregnancy has been doc ...
Article GUID: 39303770
Author(s): Daniels WMU; Ajonijebu DC; Olajide OJ;
No abstract available
Article GUID: 38445046
Author(s): Olajide OJ; La Rue C; Bergdahl A; Chapman CA;
Increasing evidence suggests that mitochondrial dysfunction and aberrant release of mitochondrial reactive oxygen species (ROS) play crucial roles in early synaptic perturbations and neuropathology that drive memory deficits in Alzheimer's disease (AD). ...
Article GUID: 36275011
Author(s): Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA;
Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex. Reductions in estrogens may alter cognit ...
Article GUID: 35939438
Author(s): Olajide OJ; Chapman CA;
The hippocampus and entorhinal cortex (EC) accumulate amyloid beta peptides (Aß) that promote neuropathology in Alzheimer's disease, but the early effects of Aß on excitatory synaptic transmission in the EC have not been well characterized. To assess th ...
Article GUID: 34144329
Author(s): Olajide OJ; Alliy ZO; Ojo DO; Osinubi OO; Bello SO; Ibrahim FE; Adukwu FO; Abikoye TO; Gbadamosi IT; Mutholib NY; Bamisi O; Ajiboye OJ; Okes ...
Despite reports that quinoline antimalarials including chloroquine (Chq) exhibit idiosyncratic neuropsychiatric effects even at low doses, the drug continues to be in widespread use during pregnanc ...
Article GUID: 33845156
Author(s): Olajide OJ, Suvanto ME, Chapman CA
The entorhinal cortex (EC) is a vital component of the medial temporal lobe, and its contributions to cognitive processes and memory formation are supported through its extensive interconnections with the hippocampal formation. During the pathogenesis of Al ...
Article GUID: 33495355
Author(s): Olajide OJ, Gbadamosi IT, Yawson EO, Arogundade T, Lewu FS, Ogunrinola KY, Adigun OO, Bamisi O, Lambe E, Arietarhire LO, Oluyomi OO, Idowu O ...
The hallmarks of Alzheimer's disease (AD) pathology include senile plaques accumulation and neurofibrillary tangles, which is thought to underlie synaptic failure. Recent evidence however suppo ...
Article GUID: 33420680
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