Author(s): Mohideen FI; Kwan DH;

The sugar moieties of many glycosylated small molecule natural products are essential for their biological activity. Glycosyltransferases (GTs) are the enzymes responsible for installing these sugar moieties on a variety of biomolecules. Several GTs that are active on natural products are inherently substrate-promiscuous and thus serve as useful tools in ...

Article GUID: 36682498

Author(s): Ouadhi S; López DMV; Mohideen FI; Kwan DH;

Many glycosylated small molecule natural products and glycoprotein biologics are important in a broad range of therapeutic and industrial applications. The sugar moieties that decorate these compounds often show a profound impact on their biological functions, thus biocatalytic methods for controlling their glycosylation are valuable. Enzymes from nature ...

Article GUID: 36444941

Author(s): Mohideen FI; Nguyen LH; Richard JD; Ouadhi S; Kwan DH;

Many small molecule natural products are decorated with sugar moieties that are essential for their biological activity. A considerable number of natural product glycosides and their derivatives are clinically important therapeutics. Anthracyclines like daunorubicin and doxorubicin are examples of valuable glycosylated natural products used in medicine as ...

Article GUID: 34751552