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Secondary Structure Stabilization of Macrocyclic Antimicrobial Peptides via Cross-Link Swapping

Author(s): Nazeer N; Kooner N; Ghimire A; Rainey JK; Lubell WD; Meneksedag-Erol D; Ahmed M;

Lactam cross-links have been employed to stabilize the helical secondary structure and enhance the activity and physiological stability of antimicrobial peptides; however, stabilization of ß-sheets via lactamization has not been observed. In the present study, lactams between the side chains of C- and N-terminal residues have been used to stabilize the ß- ...

Article GUID: 38771638


Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics.

Author(s): Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Biomedicines. 2019 Oct 18;7(4): Authors: Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Article GUID: 31635379


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