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TRAPPing a neurological disorder: from yeast to humans.

Author(s): Lipatova Z, Van Bergen N, Stanga D, Sacher M, Christodoulou J, Segev N

Autophagy. 2020 Mar 02;: Authors: Lipatova Z, Van Bergen N, Stanga D, Sacher M, Christodoulou J, Segev N

Article GUID: 32116085


Deficiencies in vesicular transport mediated by TRAPPC4 are associated with severe syndromic intellectual disability.

Author(s): Van Bergen NJ, Guo Y, Al-Deri N, Lipatova Z, Stanga D, Zhao S, Murtazina R, Gyurkovska V, Pehlivan D, Mitani T, Gezdirici A, Antony J, Collins F, Willis MJH, Coban Akdemir ZH, Liu P, Punetha J, Hunter JV, Jhangiani SN, Fatih JM, Rosenfel ...

The conserved transport protein particle (TRAPP) complexes regulate key trafficking events and are required for autophagy. TRAPPC4, like its yeast Trs23 orthologue, is a core component of the TRAPP complexes and one of the essential subunits for guanine nucleotide exchange factor activity for Rab ...

Article GUID: 31794024


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