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Lung fibrosis: drug screening and disease biomarker identification with a lung slice culture model and subtracted cDNA Library

Author(s): Guo T; Lok KY; Yu C; Li Z;

Pulmonary fibrosis is a progressive and irreversible disorder with no appropriate cure. A practical and effective experimental model that recapitulates the disease will greatly benefit the research community and, ultimately, patients. In this study, we tested the lung slice culture (LSC) system for its potential use in drug screening and disease biomarker ...

Article GUID: 25290944


NSF evaluation of gadolinium biodistribution in renally impaired rats: Using novel metabolic Gd2O3 nanoparticles coated with β-cyclodextrin (Gd2O3@PCD) in MR molecular imaging

Author(s): Ashouri H; Riyahi Alam N; Khoobi M; Haghgoo S; Rasouli Z; Gholami M;

The use of conventional gadolinium(Gd)-based contrast agents in magnetic resonance imaging (MRI) poses a significant risk of Nephrogenic Systemic Fibrosis (NSF) syndrome in patients with impaired renal function (grades 4 and 5). To address this issue, a new study has introduced a novel metabolic Gadolinium oxide nanoparticle (Gd2O3 NPs) coated with ß-cycl ...

Article GUID: 38215955


Effects of electron acceptors and donors on anaerobic biodegradation of PAHs in marine sediments

Author(s): Chen Q; Li Z; Chen Y; Liu M; Yang Q; Zhu B; Mu J; Feng L; Chen Z;

Polycyclic aromatic hydrocarbons (PAHs) are typical organic pollutants accumulated in the environment. PAHs' bioremediation in sediments can be promoted by adding electron acceptor (EA) and electron donor (ED). Bicarbonate and sulfate were chosen as two EAs, and acetate and lactate were selected as two EDs. Six groups of amendments were added into the ...

Article GUID: 38113802


Degradation of enrofloxacin by a novel Fe-N-C@ZnO material in freshwater and seawater: Performance and mechanism

Author(s): Geng C; Chen Q; Li Z; Liu M; Chen Z; Tao H; Yang Q; Zhu B; Feng L;

In this study, we investigated the doping of Fe-N-C with ZnO (Fe-N-C@ZnO) to enhance its performance in the reduction of biological toxicity and degradation of enrofloxacin (ENR) in seawater. The steady-state/transient fluorescence analysis and free radical quenching test indicated an extremely low electron-hole recombination rate and the generation of re ...

Article GUID: 37619630


Health behavior profiles in young survivors of childhood cancer: Findings from the St. Jude Lifetime Cohort Study

Author(s): Webster RT; Dhaduk R; Gordon ML; Partin RE; Kunin-Batson AS; Brinkman TM; Willard VW; Allen JM; Alberts NM; Lanctot JQ; Ehrhardt MJ; Li Z; Hudson MM; Robison LL; Ness KK;

Background: There is limited understanding of associations between a combination of health behaviors (physical activity, sedentary/screen-time, diet) and cardiometabolic health risk factors, physical performance, and emotional health among young (<18) childhood cancer survivor ...

Article GUID: 36943740


Lymph Node Metastases Detection Using Gd2O3@PCD as Novel Multifunctional Contrast Imaging Agent in Metabolic Magnetic Resonance Molecular Imaging

Author(s): Rasouli Z; Riyahi-Alam N; Khoobi M; Haghgoo S; Gholibegloo E; Ebrahimpour A; H A; Hashemi H;

Axillary lymph node detection is crucial to staging and prognosis of the lymph node metastatic spread in breast cancer. Currently, lymphoscintigraphy and blue dye, as the conventional methods to localize sentinel lymph nodes (SLNs), are invasive and can only be performed during surgery. This stud ...

Article GUID: 36304774


Indoor exposure to selected flame retardants and quantifying importance of environmental, human behavioral and physiological parameters

Author(s): Li Z; Zhang X; Wang B; Shen G; Zhang Q; Zhu Y;

Indoor exposure to organic flame retardants (FRs) has raised extensive concern due to associated adverse health effects. Indoor-exposure induced daily intakes of six widely used FRs individually ranged 0.002-611 ng/day and 0.02-463 ng/day, respectively, for adults and 2-6-year-old children; and resulting internal exposure levels ranged 0.1-159 and 2.1-450 ...

Article GUID: 35461943


Modeling of Flame Retardants in Typical Urban Indoor Environments in China during 2010-2030: Influence of Policy and Decoration and Implications for Human Exposure

Author(s): Li Z; Zhu Y; Wang D; Zhang X; Jones KC; Ma J; Wang P; Yang R; Li Y; Pei Z; Zhang Q; Jiang G;

Novel flame retardants (FRs) are of increasing concern, given growing evidence of health effects and use to replace polybrominated diphenyl ethers (PBDEs). This study modeled combined effects of use policies and decoration on indoor FRs and human exposure for 18 widely used PBDEs, organophosphate ...

Article GUID: 34410710


Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease

Author(s): Scott BM; Gutiérrez-Vázquez C; Sanmarco LM; da Silva Pereira JA; Li Z; Plasencia A; Hewson P; Cox LM; O' Brien M; Chen SK; Moraes-Vieira PM; Chang BSW; Peisajovich SG; Quintana FJ;

Inflammatory bowel disease (IBD) is a complex chronic inflammatory disorder of the gastrointestinal tract. Extracellular adenosine triphosphate (eATP) produced by the commensal microbiota and host cells activates purinergic signaling, promoting intestinal inflammation and pathology. Based on the ...

Article GUID: 34183837


Change in Pain Status and Subsequent Opioid and Marijuana Use Among Long-Term Adult Survivors of Childhood Cancer.

Author(s): Huang IC, Alberts NM, Buckley MG, Li Z, Ehrhardt MJ, Brinkman TM, Allen J, Krull KR, Klosky JL, Greene WL, Srivastava DK, Robison LL, Hudson MM, Anghelescu DL

We evaluated pain status change and associations with subsequent opioid/marijuana use among 1208 adult survivors of childhood cancer. Pain status and opioid/marijuana were self-reported at baseline and follow-up evaluation (mean interval = 4.2?years). Over time, 18.7% of survivors endorsed persis ...

Article GUID: 33409451


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