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Exploring global oceanic persistence and ecological effects of legacy persistent organic pollutants across five decades

Author(s): Zhang X; Li L; Xie Z; Ma J; Li YF; Cai M; Ren NQ; Kallenborn R; Zhang ZF; Zhang X; C G Muir D;

Global monitoring of persistent organic pollutants (POPs) has intensified following regulatory efforts aimed at reducing their release. In this context, we compiled over 10,000 POP measurements, reported from 1980 to 2023, to assess the effectiveness of these legislative measures in the global ma ...

Article GUID: 39321284


A Pilot Randomized Trial of Combined Cognitive-Behavioral Therapy and Exercise Training Versus Exercise Training Alone for the Management of Chronic Insomnia in Obstructive Sleep Apnea

Author(s): Cammalleri A; Perrault AA; Hillcoat A; Carrese-Chacra E; Tarelli L; Patel R; Baltzan M; Chouchou F; Dang-Vu TT; Gouin JP; Pepin V;

Insomnia treatment among individuals with comorbid insomnia and obstructive sleep apnea is suboptimal. In a pilot randomized controlled trial, 19 individuals with comorbid insomnia and obstructive sleep apnea were allocated to one of two arms: EX + EX, consisting of two 8-week phases of exercise ...

Article GUID: 38663849


Methodological approach to sleep state misperception in insomnia disorder: Comparison between multiple nights of actigraphy recordings and a single night of polysomnography recording

Author(s): Maltezos A; Perrault AA; Walsh NA; Phillips EM; Gong K; Tarelli L; Smith D; Cross NE; Pomares FB; Gouin JP; Dang-Vu TT;

Study objective: To provide a comprehensive assessment of sleep state misperception in insomnia disorder (INS) and good sleepers (GS) by comparing recordings performed for one night in-lab (PSG and night review) and during several nights at-home (actigraphy and sleep diaries). Methods: Fifty-sev ...

Article GUID: 38325157


Adolescent anxiety and pain problems: A joint, genome-wide investigation and pathway-based analysis

Author(s): Mascheretti S; Forni D; Lampis V; Fumagalli L; Paquin S; Andlauer TFM; Wang W; Dionne G; Brendgen MR; Vitaro F; Ouellet-Morin I; Rouleau G; Gouin JP; Côté S; Tremblay RE; Turecki G; Garon-Carrier G; Boivin M; Battaglia M;

Both common pain and anxiety problems are widespread, debilitating and often begin in childhood-adolescence. Twin studies indicate that this co-occurrence is likely due to shared elements of risk, rather than reciprocal causation. A joint genome-wide investigation and pathway/network-based analys ...

Article GUID: 37146008


A Small Molecule Inhibitor of Erg251 Makes Fluconazole Fungicidal by Inhibiting the Synthesis of the 14α-Methylsterols

Author(s): Lu H; Li W; Whiteway M; Wang H; Zhu S; Ji Z; Feng Y; Yan L; Fang T; Li L; Ni T; Zhang X; Lv Q; Ding Z; Qiu L; Zhang D; Jiang Y;

Fluconazole (FLC) is widely used to prevent and treat invasive fungal infections. However, FLC is a fungistatic agent, allowing clinical FLC-susceptible isolates to tolerate FLC. Making FLC fungicidal in combination with adjuvants is a promising strategy to avoid FLC resistance and eliminate the ...

Article GUID: 36475771


Effects of cognitive behavioral therapy for insomnia on subjective and objective measures of sleep and cognition

Author(s): Perrault AA; Pomares FB; Smith D; Cross NE; Gong K; Maltezos A; McCarthy M; Madigan E; Tarelli L; McGrath JJ; Savard J; Schwartz S; Gouin JP; Dang-Vu TT;

Study objectives: To assess the effects of Cognitive Behavioral Therapy for insomnia (CBTi) on subjective and objective measures of sleep, sleep-state misperception and cognitive performance. Methods: We performed a randomized-controlled trial with a treatment group and a wait-list control group ...

Article GUID: 35691208


Uncovering global-scale risks from commercial chemicals in air

Author(s): Liu Q; Li L; Zhang X; Saini A; Li W; Hung H; Hao C; Li K; Lee P; Wentzell JJB; Huo C; Li SM; Harner T; Liggio J;

Commercial chemicals are used extensively across urban centres worldwide1, posing a potential exposure risk to 4.2 billion people2. Harmful chemicals are often assessed on the basis of their environmental persistence, accumulation in biological organisms and toxic properties, under international ...

Article GUID: 34912090


Fast oscillations >40 Hz localize the epileptogenic zone: An electrical source imaging study using high-density electroencephalography.

Author(s): Avigdor T, Abdallah C, von Ellenrieder N, Hedrich T, Rubino A, Lo Russo G, Bernhardt B, Nobili L, Grova C, Frauscher B

OBJECTIVE: Fast Oscillations (FO) >40 Hz are a promising biomarker of the epileptogenic zone (EZ). Evidence using scalp electroencephalography (EEG) remains scarce. We assessed if electrical source imaging of FO using 256-channel high-density EEG (HD-EEG) is useful for EZ identification. METHODS: ...

Article GUID: 33450578


Depression prevalence based on the Edinburgh Postnatal Depression Scale compared to Structured Clinical Interview for DSM DIsorders classification: Systematic review and individual participant data meta-analysis

Author(s): Lyubenova A; Neupane D; Levis B; Wu Y; Sun Y; He C; Krishnan A; Bhandari PM; Negeri Z; Imran M; Rice DB; Azar M; Chiovitti MJ; Saadat N; Riehm KE; Boruff JT; Ioannidis JPA; Cuijpers P; Gilbody S; Kloda LA; Patten SB; Shrier I; Ziegelstei ...

Objectives: Estimates of depression prevalence in pregnancy and postpartum are based on the Edinburgh Postnatal Depression Scale (EPDS) more than on any other method. We aimed to determine if any EPDS cutoff can accurately and consistently estimate depression prevalence in individual studies. Me ...

Article GUID: 33089942


Contactless Capacitive Electrocardiography Using Hybrid Flexible Printed Electrodes.

Author(s): Lessard-Tremblay M, Weeks J, Morelli L, Cowan G, Gagnon G, Zednik RJ

Traditional capacitive electrocardiogram (cECG) electrodes suffer from limited patient comfort, difficulty of disinfection and low signal-to-noise ratio in addition to the challenge of integrating them in wearables. A novel hybrid flexible cECG electrode was developed that offers high versatility in the integration method, is well suited for large-scale m ...

Article GUID: 32927651


The antibacterial activity of p-tert-butylcalix[6]arene and its effect on a membrane model: molecular dynamics and Langmuir film studies.

Author(s): Wrobel EC, de Lara LS, do Carmo TAS, Castellen P, Lazzarotto M, de Lázaro SR, Camilo A, Caseli L, Schmidt R, DeWolf CE, Wohnrath K

Phys Chem Chem Phys. 2020 Mar 03;: Authors: Wrobel EC, de Lara LS, do Carmo TAS, Castellen P, Lazzarotto M, de Lázaro SR, Camilo A, Caseli L, Schmidt R, DeWolf CE, Wohnrath K

Article GUID: 32124897


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