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What is Learned Determines How Pavlovian Conditioned Fear is Consolidated in the Brain

Author(s): Leake J; Leidl DM; Lay BPP; Fam JP; Giles MC; Qureshi OA; Westbrook RF; Holmes NM;

Activity in the basolateral amygdala complex (BLA) is needed to encode fears acquired through contact with both innate sources of danger (i.e., things that are painful) and learned sources of danger (e.g., being threatened with a gun). However, within the BLA, the molecular processes required to consolidate the two types of fear are not the same: protein ...

Article GUID: 37963767


The Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala During the First Extinction Episode Has Persistent Effects on Extinction Expression

Author(s): Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD;

Background: Adaptive behavior depends on the delicate and dynamic balance between acquisition and extinction memories. Disruption of this balance, particularly when the extinction of memory loses control over behavior, is the root of treatment failure of maladaptive behaviors such as substance abuse or anxiety disorders. Understanding this balance require ...

Article GUID: 36336498


Correction to: Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

No abstract

Article GUID: 36006415


Experimental chambers Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

Rationale and objective: Learning to inhibit acquired fear responses is fundamental to adaptive behavior. Two procedures that support such learning are extinction and overexpectation. In extinction, an expected outcome is omitted, whereas in overexpectation two individually trained cues are presented in compound to induce an expectation of a greater outco ...

Article GUID: 35932299


Understanding Associative Learning Through Higher-Order Conditioning

Author(s): Gostolupce D; Lay BPP; Maes EJP; Iordanova MD;

Associative learning is often considered to require the physical presence of stimuli in the environment in order for them to be linked. This, however, is not a necessary condition for learning. Indeed, associative relationships can form between events that are never directly paired. That is, associative learning can occur by integrating information across ...

Article GUID: 35517574


Mechanisms of higher-order learning in the amygdala

Author(s): Gostolupce D; Iordanova MD; Lay BPP;

Adaptive behaviour is under the potent control of environmental cues. Such cues can acquire value by virtue of their associations with outcomes of motivational significance, be they appetitive or aversive. There are at least two ways through which an environmental cue can acquire value, through first-order and higher-order conditioning. In first-order con ...

Article GUID: 34197867


Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2018 Oct 29;: Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Article GUID: 30371757


Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2019 Apr 01;29(4):1703 Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD PMID: 30590441 [PubMed - in process]

Article GUID: 30590441


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