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The Adr1 transcription factor directs regulation of the ergosterol pathway and azole resistance in Candida albicans

Author(s): Shrivastava M; Kouyoumdjian GS; Kirbizakis E; Ruiz D; Henry M; Vincent AT; Sellam A; Whiteway M;

Transcription factors (TFs) play key roles in cellular regulation and are critical in the control of drug resistance in the fungal pathogen Candida albicans. We found that activation of the transcription factor C4_02500C_A (Adr1) conferred significant resistance against fluconazole. In Saccharomy ...

Article GUID: 37791798


Trauma-informed Approaches to Substance Use Interventions with Indigenous Peoples: A Scoping Review

Author(s): Pride T; Lam A; Swansburg J; Seno M; Lowe MB; Bomfim E; Toombs E; Marsan S; LoRusso J; Roy J; Gurr E; LaFontaine J; Paul J; Burack JA; Mushquash C; Stewart SH; Wendt DC;

Indigenous Peoples experience disproportionately higher rates of problematic substance use. These problems are situated in a context of individual and intergenerational trauma from colonization, residential schools, and racist and discriminatory practices, policies, and services. Therefore, subst ...

Article GUID: 34895091


Loss of Arp1, a putative actin-related protein, triggers filamentous and invasive growth and impairs pathogenicity in Candida albicans.

Author(s): Yao S, Feng Y, Islam A, Shrivastava M, Gu H, Lu Y, Sheng J, Whiteway M, Feng J

The polymorphous cellular shape of Candida albicans, in particular the transition from a yeast to a filamentous form, is crucial for either commensalism or life-threatening infections of the host. Various external or internal stimuli, including serum and nutrition starvation, have been shown to regulate filamentous growth primarily through two classical s ...

Article GUID: 33363697


The Canadian Fungal Research Network: current challenges and future opportunities.

Author(s): Horianopoulos LC, Gluck-Thaler E, Benoit Gelber I, Cowen LE, Geddes-McAlister J, Landry CR, Schwartz IS, Scott JA, Sellam A, Sheppard DC, Spribille T, Subramaniam R, Walker AK, Harris SD, Shapiro RS, Gerstein A

Can J Microbiol. 2020 Jul 27;: Authors: Horianopoulos LC, Gluck-Thaler E, Benoit Gelber I, Cowen LE, Geddes-McAlister J, Landry CR, Schwartz IS, Scott JA, Sellam A, Sheppard DC, Spribille T, Subramaniam R, Walker AK, Harris SD, Shapiro RS, Gerstein A

Article GUID: 32717148


Hof1 plays a checkpoint related role in MMS induced DNA damage response in Candida albicans.

Author(s): Feng J, Islam A, Bean B, Feng J, Sparapani S, Shrivastava M, Goyal A, Omran RP, Mallick J, Whiteway M

Mol Biol Cell. 2020 Jan 15;:mbcE19060316 Authors: Feng J, Islam A, Bean B, Feng J, Sparapani S, Shrivastava M, Goyal A, Omran RP, Mallick J, Whiteway M

Article GUID: 31940254


The Genomic Landscape of the Fungus-Specific SWI/SNF Complex Subunit, Snf6, in Candida albicans.

Author(s): Tebbji F, Chen Y, Sellam A, Whiteway M

mSphere. 2017 Nov-Dec;2(6): Authors: Tebbji F, Chen Y, Sellam A, Whiteway M

Article GUID: 29152582


Integration of Growth and Cell Size via the TOR Pathway and the Dot6 Transcription Factor in Candida albicans.

Author(s): Chaillot J, Tebbji F, Mallick J, Sellam A

Genetics. 2019 02;211(2):637-650 Authors: Chaillot J, Tebbji F, Mallick J, Sellam A

Article GUID: 30593490


Functional divergence of a global regulatory complex governing fungal filamentation.

Author(s): Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim SH, Tebbji F, Sellam A, Todd RT, Xie JL, Lin ZY, Wong CJ, Shapiro RS, Whiteway M, Robbins N, Gingras AC, Selmecki A, Cowen LE

Functional divergence of a global regulatory complex governing fungal filamentation.

PLoS Genet. 2019 01;15(1):e1007901

Authors: Polvi EJ, Veri AO, Liu Z, Hossain S, Hyde S, Kim SH, Tebbji F, Sellam A, Todd RT, Xie JL, Lin ZY, Wong CJ, Shapiro RS, Whiteway M, Robbins N, Gingra ...

Article GUID: 30615616


Mms21: A Putative SUMO E3 Ligase in Candida albicans That Negatively Regulates Invasiveness and Filamentation, and Is Required for the Genotoxic and Cellular Stress Response.

Author(s): Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Genetics. 2019 02;211(2):579-595 Authors: Islam A, Tebbji F, Mallick J, Regan H, Dumeaux V, Omran RP, Whiteway M

Article GUID: 30530734


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