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Robustness and evolvability: Revisited, redefined and applied

Author(s): Kharma N; Bédard-Couture R;

Building on and extending existing definitions of robustness and evolvability, we propose and utilize new formal definitions, with matching measures, of robustness and evolvability of systems with genotypes and corresponding phenotypes. We explain and show how these measures are more general and more representative of the concepts they stand for, than the ...

Article GUID: 39098381


BioCloneBot: A versatile, low-cost, and open-source automated liquid handler

Author(s): Wells KC; Kharma N; Jaunky BB; Nie K; Aguiar-Tawil G; Berry D;

Liquid handler systems can provide significant benefits to researchers by automating laboratory work, however, their unaffordable price provides a steep barrier to entry. Therefore, we provide the BioCloneBot, a versatile, low-cost, and open-source automated liquid handler. This system can be easily built with 3D-printed parts and readily available commer ...

Article GUID: 38524156


Digital Microfluidics Chips for the Execution and Real-Time Monitoring of Multiple Ribozymatic Cleavage Reactions

Author(s): Davis AN; Samlali K; Kapadia JB; Perreault J; Shih SCC; Kharma N;

In this paper, we describe the design and performance of two digital microfluidics (DMF) chips capable of executing multiple ribozymatic reactions, with proper controls, in response to short single-stranded DNA inducers. Since the fluorescence output of a reaction is measurable directly from the chip, without the need for gel electrophoresis, a complete e ...

Article GUID: 34514224


Computer-Aided Design of Active Pseudoknotted Hammerhead Ribozymes.

Author(s): Najeh S, Zandi K, Djerroud S, Kharma N, Perreault J

Methods Mol Biol. 2021;2167:91-111 Authors: Najeh S, Zandi K, Djerroud S, Kharma N, Perreault J

Article GUID: 32712917


An Adaptive Defect Weighted Sampling Algorithm to Design Pseudoknotted RNA Secondary Structures.

Author(s): Zandi K, Butler G, Kharma N

Front Genet. 2016;7:129 Authors: Zandi K, Butler G, Kharma N

Article GUID: 27499762


RNA-Based Therapy Utilizing Oculopharyngeal Muscular Dystrophy Transcript Knockdown and Replacement.

Author(s): Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA

Mol Ther Nucleic Acids. 2019 Apr 15;15:12-25 Authors: Abu-Baker A, Kharma N, Perreault J, Grant A, Shekarabi M, Maios C, Dona M, Neri C, Dion PA, Parker A, Varin L, Rouleau GA

Article GUID: 30831428


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