Author(s): Memari E; Helfield B;
The recent and exciting success of anti-inflammatory therapies for ischemic heart disease (e.g. atherosclerosis) is hindered by the lack of site-specific and targeted therapeutic deposition. Microbubble-mediated focused ultrasound, which uses circulating, l ...
Article GUID: 38988819
Author(s): Singh D; Memari E; He S; Yusefi H; Helfield B;
Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explo ...
Article GUID: 38983873
Author(s): Memari E; Khan D; Alkins R; Helfield B;
Focused ultrasound (FUS) combined with intravascularly circulating microbubbles can transiently increase the permeability of the blood-brain barrier (BBB) to enable targeted therapeutic delivery to the brain, the clinical testing of which is currently under ...
Article GUID: 38266715
Author(s): Yusefi H; Helfield B;
Phospholipid encapsulated ultrasound contrast agents have proven to be a powerful addition in diagnostic imaging and show emerging applications in targeted therapy due to their resonant and nonlinear scattering. Microbubble response is affected by their int ...
Article GUID: 38217906
Author(s): Helfield B; Sirsi S; Kwan J; Gray M;
Welcome to this special issue on Cavitation-Enhanced Drug Delivery and Immunotherapy-a rapidly evolving area that has been buoyed in recent years by the development of methods harnessing the activity of ultrasound-stimulated bubbles known as cavitation [...].
Article GUID: 37765176
Author(s): Memari E; Hui F; Yusefi H; Helfield B;
The local fluid dynamics experienced by circulating microbubbles vary across different anatomical sites, which can influence ultrasound-mediated therapeutic delivery efficacy. This study aimed to elucidate the effect of fluid flow rate in combination with r ...
Article GUID: 37150403
Author(s): He S; Singh D; Yusefi H; Helfield B;
In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia. Novel ultrasound-stimulated microbubbles offer a means to deli ...
Article GUID: 36559150
Author(s): Yusefi H; Helfield B;
Ultrasound-driven microbubbles, typically between 1 and 8 µm in diameter, are resonant scatterers that are employed as diagnostic contrast agents and emerging as potentiators of targeted therapies. Microbubbles are administered in populations whereby their ...
Article GUID: 36223708
Author(s): He S; Singh D; Helfield B;
Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease. Indeed, the plasma membrane represents a significant barrier to successful del ...
Article GUID: 35456718
Author(s): Wei L; Williams R; Loupas T; Helfield B; Burns PN;
Doppler ultrasound has become a standard method used to diagnose and grade vascular diseases and monitor their progression. Conventional focused-beam color Doppler imaging is routinely used in clinical practice, but suffers from inherent trade-offs between ...
Article GUID: 34006440
Author(s): Helfield B, Chen X, Watkins SC, Villanueva FS
Ultrasound Med Biol. 2020 May 10;: Authors: Helfield B, Chen X, Watkins SC, Villanueva FS
Article GUID: 32402675
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