Author(s): Baez A; Singh D; He S; Hajiaghayi M; Gholizadeh F; Darlington PJ; Helfield B;

While met with initial and ground-breaking success targeting blood borne cancers, cellular immunotherapy remains significantly hindered in the context of solid tumors by the tumor microenvironment. Focused ultrasound, in conjunction with microbubbles, has found tremendous potential as a targeted and local drug/gene delivery technique for cancer therapy. T ...

Article GUID: 39502696

Author(s): Singh D; Memari E; He S; Yusefi H; Helfield B;

Over the past two decades, there has been tremendous and exciting progress toward extending the use of medical ultrasound beyond a traditional imaging tool. Ultrasound contrast agents, typically used for improved visualization of blood flow, have been explored as novel non-viral gene delivery vectors for cardiovascular therapy. Given this adaptation to ul ...

Article GUID: 38983873

Author(s): Wang S; Orabi EA; Baday S; Bernèche S; Lamoureux G;

Proteins of the Amt/MEP family facilitate ammonium transport across the membranes of plants, fungi, and bacteria and are essential for growth in nitrogen-poor environments. Some are known to facilitate the diffusion of the neutral NH(3), while others, notably in plants, transport the positively charged NH(4)(+). On the basis of the structural data for Amt ...

Article GUID: 22631217

Author(s): He S; Singh D; Yusefi H; Helfield B;

In endothelial cells, microRNA-126 (miR-126) promotes angiogenesis, and modulating the intracellular levels of this gene could suggest a method to treat cardiovascular diseases such as ischemia. Novel ultrasound-stimulated microbubbles offer a means to deliver therapeutic payloads to target cells and sites of disease. The purpose of this study was to inve ...

Article GUID: 36559150

Author(s): He S; Rucker DD;

Uncertainty is an inherent part of consumers' environment. A large literature in marketing and related disciplines has found a positive relationship between uncertainty and information search: as consumers' uncertainty about a brand, product, or service increases, so does their inclination to seek out and engage with information. In contrast to th ...

Article GUID: 36471868

Author(s): He S; Singh D; Helfield B;

Localized and reversible plasma membrane disruption is a promising technique employed for the targeted deposition of exogenous therapeutic compounds for the treatment of disease. Indeed, the plasma membrane represents a significant barrier to successful delivery, and various physical methods using light, sound, and electrical energy have been developed to ...

Article GUID: 35456718