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Otilonium Bromide Exhibits Potent Antifungal Effects by Blocking Ergosterol Plasma Membrane Localization and Triggering Cytotoxic Autophagy in Candida Albicans

Author(s): Zhen C; Wang L; Feng Y; Whiteway M; Hang S; Yu J; Lu H; Jiang Y;

Candidiasis, which presents a substantial risk to human well-being, is frequently treated with azoles. However, drug-drug interactions caused by azoles inhibiting the human CYP3A4 enzyme, together with increasing resistance of Candida species to azoles, represent serious issues with this class of drug, making it imperative to develop innovative antifungal ...

Article GUID: 38995235


Parents' reading-related knowledge and children's reading acquisition

Author(s): Ladd M; Martin-Chang S; Levesque K;

Teacher reading-related knowledge (phonological awareness and phonics knowledge) predicts student reading, however little is known about the reading-related knowledge of parents. Participants comprised 70 dyads (children from kindergarten and grade 1 and their parents). Parents were administered a questionnaire tapping into reading-related knowledge, prin ...

Article GUID: 21678121


Thinking aloud: effects on text comprehension by children with specific language impairment and their peers

Author(s): McClintock B; Pesco D; Martin-Chang S;

Background: Many lines of evidence now suggest that inferencing plays a substantial role in text comprehension. However, inferencing appears to be difficult for children with language impairments, many of whom are also struggling readers. Aims: To assess the effects of a 'think-aloud' procedure on inference generation and narrative text comprehen ...

Article GUID: 25180778


Candidiasis: from cutaneous to systemic, new perspectives of potential targets and therapeutic strategies

Author(s): Lu H; Hong T; Jiang Y; Whiteway M; Zhang S;

Candidiasis is an infection caused by fungi from a Candida species, most commonly Candida albicans. C. albicans is an opportunistic fungal pathogen typically residing on human skin and mucous membranes of the mouth, intestines or vagina. It can cause a wide variety of mucocutaneous barrier and systemic infections; and becomes a severe health problem in HI ...

Article GUID: 37307922


From Storybooks to Novels: A Retrospective Approach Linking Print Exposure in Childhood to Adolescence

Author(s): Tremblay B; Rodrigues ML; Martin-Chang S;

Despite the far-reaching advantages associated with leisure reading, it is an activity that fewer adolescents are choosing to pursue. The present study used a retrospective correlational approach to investigate shared storybook reading in childhood and current print exposure in 45 parent-adolescent dyads. Parents and adolescents completed a Retrospective ...

Article GUID: 33071904


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