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Candida albicans exhibits heterogeneous and adaptive cytoprotective responses to anti-fungal compounds

Author(s): Dumeaux V; Massahi S; Bettauer V; Mottola A; Dukovny A; Khurdia SS; Costa ACBP; Omran RP; Simpson S; Xie JL; Whiteway M; Berman J; Hallett MT;

Candida albicans, an opportunistic human pathogen, poses a significant threat to human health and is associated with significant socio-economic burden. Current antifungal treatments fail, at least in part, because C. albicans can initiate a strong drug tolerance response that allows some cells to ...

Article GUID: 37888959


A metagenomic-based study of two sites from the Barbadian reef system

Author(s): Simpson S; Bettauer V; Ramachandran A; Kraemer S; Mahon S; Medina M; Vallès Y; Dumeaux V; Vallès H; Walsh D; Hallett MT;

We study the microbiome of sea water collected from two locations of the Barbadian coral reefs. The two sites differ in several environmental and ecological variables including their endogenous benthic community and their proximity to urban development and runoffs from inland watersheds. The comp ...

Article GUID: 37009568


A Deep Learning Approach to Capture the Essence of Candida albicans Morphologies

Author(s): Bettauer V; Costa ACBP; Omran RP; Massahi S; Kirbizakis E; Simpson S; Dumeaux V; Law C; Whiteway M; Hallett MT;

We present deep learning-based approaches for exploring the complex array of morphologies exhibited by the opportunistic human pathogen Candida albicans. Our system, entitled Candescence, automatically detects C. albicans cells from differential image contrast microscopy and labels each detected ...

Article GUID: 35972285


The Complex Subtype-Dependent Role of Connexin 43 (GJA1) in Breast Cancer.

Author(s): Busby M, Hallett MT, Plante I

Int J Mol Sci. 2018 Feb 28;19(3): Authors: Busby M, Hallett MT, Plante I

Article GUID: 29495625


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