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Longitudinal effects of cerebrovascular reactivity and cerebral pulsatility in cognitively intact older adults with APOE4: links with cognition

Author(s): Potvin-Jutras Z; Tremblay PL; Mohammadi H; Villeneuve S; Spreng RN; Gauthier CJ;

The apolipoprotein E4 (APOE4) allele is the strongest genetic risk factor for Alzheimer's disease (AD) and is linked to poorer cerebrovascular health. Cerebrovascular reactivity (CVR), an indicator of vascular reserve, and cerebral pulsatility (CP), a marker of vascular stiffness, are sensitive biomarkers of early vascular dysfunction associated with ...

Article GUID: 41353310


Symptom burden, healthcare utilization, and risky behaviors in survivors of the childhood cancer survivor study (CCSS): an observation cohort study

Author(s): Webster R; Srivastava DK; Xie L; Darji H; Liu W; McGrady ME; Brinkman TM; Alberts NM; Ness KK; Fuemmeler B; Kunin-Batson AS; Huang IC; Armstrong GT; Howell RM; Green DM; Yasui Y; Krull KR;

Background: Childhood cancer survivors face physical, psychological, and neurological symptoms that contribute to risky health behaviors and increased healthcare utilization. Traditional survivorship care models overlook risk associated with this symptom burden. The current study examined symptom ...

Article GUID: 41340862


Geography, Ancestry, Age and Sex Shape Somatic Autosomal Mosaic Chromosomal Alterations in Blood

Author(s): Won Kang JR; Kim YJ; Skead K; Soave D; Evans J; Bruat V; Harwood MP; Morris Q; Matovu E; Mulindwa J; Noyes H; McLeod A; Hazelhurst S; Lombard Z; Ramsay M; Fave MJ; Awadalla P;

Clonal hematopoiesis, through the age-associated accumulation of somatic mutations in blood, is strongly associated with hematological malignancies and other chronic diseases. These mutations have largely been characterized in individuals of European ancestry or environments, and consequently, it ...

Article GUID: 41282824


Trends in missed paediatric preventive primary care visits during the COVID-19 pandemic using routinely collected electronic medical records in Ontario, Canada (2015-2022)

Author(s): Bayoumi I; Mcfadden K; Valkanas H; Tu K; Kalia S; Chen T; Christie CD; Rourke J; Rourke L; Greiver M; Leduc D; Li P;

Background: Well child visits (WCV) are fundamental to preventive primary care. We examined trends in WCV attendance during the COVID-19 pandemic and characterised variation by patient and provider characteristics. Methods: Deidentified electronic medical records from two academic practice-based ...

Article GUID: 41290264


Substituted diphenylamine antioxidants and synthetic phenolic antioxidants in leachate from domestic landfills in China: Occurrence and removal via treatment

Author(s): Zhang LH; Chen F; Zhang XM; Zhang X; Liang B; Bai SS; Zhang ZF; Li YF; Ren NQ;

Substituted diphenylamine antioxidants (SDPAs) and synthetic phenolic antioxidants (SPAs), widely used in rubber and consumer products, pose growing environmental concerns. This study evaluated the occurrence and release of 43 SDPAs and 4 SPAs in raw leachate and treated effluent from 18 municipal landfills across China. Results showed 17 SDPAs and 1 SPA ...

Article GUID: 41270417


Assessment of chemical extracts of urban air for endocrine disruption using a serie of in vitro bioassays: a case study in Montreal, Canada

Author(s): Gillet AP; Dong H; Liu L; Akiki C; Zhang X; Tian L; Wania F; Wade MG; Apparicio P; Bayen S; Delbes G;

Recent data indicate that urban air harbors a complex mixture of industrial chemicals, pesticides, and combustion by-products, many of which may act as endocrine-disrupting chemicals (EDCs). By interfering with the endocrine system, EDCs can affect human health. Hence, there is an urgent need to ...

Article GUID: 41242228


From water to sediment: A meta-analysis of microplastic distribution and the impact of dams in reservoir ecosystems

Author(s): Gao W; Zhang P; Wang H; Yang X; An C;

Microplastics (MPs) have become major contaminants in freshwater ecosystems. While numerous studies have characterized MPs in reservoirs, a comprehensive synthesis focusing on in-reservoir variations and dam-related influences is still lacking. This study investigates the spatial distribution of MPs in reservoir water and sediment based on data synthesize ...

Article GUID: 41215774


Human short-term memory learning based on dynamic glutamate levels and oscillatory activities: concurrent metabolic and electrophysiological studies using event-related functional-MRS and EEG modalities

Author(s): Mohammadi H; Zargaran SJ; Khajehpour H; Adibi I; Rahimiforoushani A; Karimi S; Serej ND; Alam NR;

Short-term memory (STM) temporarily stores sensory information, critical for synaptic plasticity, memory, and learning, and is regulated by the glutamate-gated NMDA receptor. While the frontal and parieto-occipital cortices have been implicated in STM, the electrochemical dynamics of the right he ...

Article GUID: 41171530


Effects of delayed post-polymerization on physical, chemical, and biological properties of a 3D printing interim resin

Author(s): Choi Y; Comeau P; Lim BS; Manso AP; Chung SH;

Objectives: This study evaluated the effects of delayed post-polymerization on color, degree of conversion (DC), flexural strength (FS), and cellular response of a 3D-printed dental interim resin. Methods: Specimens were divided into six groups based on delays of 0 h, 2 h, 4 h, 6 h, 8 h, and 10 h before post-polymerization. Color was characterized using ...

Article GUID: 41152035


A Novel Tool Condition Monitoring Technique of Determining Insert Flank Wear Width of Indexable Face Milling Tools Using On-Machine Laser Tool Setters

Author(s): Fang T; Chen Z; Feng H; Chen P; Chang Z;

Indexable face milling tools are often used to machine workpieces with large axial and radial depth of cuts, and thus, the inserts quickly wear out in machining. A kernel technique of smart machining is tool wear compensation, which is to regularly and automatically measure the insert radius/length with a laser tool setter on the machine table during mach ...

Article GUID: 41156415


The Bug-Network (BugNet): A Global Experimental Network Testing the Effects of Invertebrate Herbivores and Fungal Pathogens on Plant Communities and Ecosystem Function in Open Ecosystems

Author(s): Kempel A; Adamidis GC; Anadón JD; Atkinson J; Auge H; Avtzis D; Bachelot B; Bashirzadeh M; Bota JL; Classen A; Constantinou I; Crawley M; de Bellis T; Dostal P; Ebeling A; Eisenhauer N; Eldridge DJ; Encina G; Estrada C; Everingham S; Fan ...

Plants are consumed by a variety of organisms, including herbivores and pathogens, which significantly impact plant biomass, diversity, community composition, and ecosystem functioning. While the impacts of vertebrate herbivores are well established, the effects of consumer groups such as insect ...

Article GUID: 41080499


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