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Neuroscience: Setting the neurobiological occasions for hierarchical learning and inference

Author(s): Ratemi M; Gardner MPH;

Hierarchical associations help animals navigate the environment by using contextual and latent states to guide learning and behavior. Chemogenetic inactivation in an occasion setting task reveals that orbitofrontal cortex is essential for implementing a hierarchical task structure, yet both orbitofrontal cortex and dorsal hippocampus are required for new ...

Article GUID: 39626624


Calcium activity is a degraded estimate of spikes

Author(s): Hart EE; Gardner MPH; Panayi MC; Kahnt T; Schoenbaum G;

Recording action potentials extracellularly during behavior has led to fundamental discoveries regarding neural function-hippocampal neurons respond to locations in space,1 motor cortex neurons encode movement direction,2 and dopamine neurons signal reward prediction errors3-observations undergirding current theories of cognition,4 movement,5 and learning ...

Article GUID: 36368324


Anterior cingulate neurons signal neutral cue pairings during sensory preconditioning

Author(s): Hart EE; Gardner MPH; Schoenbaum G;

Of all frontocortical subregions, the anterior cingulate cortex (ACC) has perhaps the most overlapping theories of function.1-3 Recording studies in rats, humans, and other primates have reported diverse neural responses that support many theories,4-12 yet nearly all these studies have in common tasks in which one event reliably predicts another. This lea ...

Article GUID: 34936884


Causal evidence supporting the proposal that dopamine transients function as temporal difference prediction errors.

Author(s): Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Nat Neurosci. 2020 Jan 20;: Authors: Maes EJP, Sharpe MJ, Usypchuk AA, Lozzi M, Chang CY, Gardner MPH, Schoenbaum G, Iordanova MD

Article GUID: 31959935


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