Reset filters

Search publications


Search by keyword
List by department / centre / faculty

No publications found.

 

TANGO2 deficiency disease is predominantly caused by a lipid imbalance

Author(s): Sacher M; DeLoriea J; Mehranfar M; Casey C; Naaz A; Gamberi C;

TANGO2 deficiency disease (TDD) is a rare genetic disorder estimated to affect ~8000 individuals worldwide. It causes neurodegeneration often accompanied by potentially lethal metabolic crises that are triggered by diet or illness. Recent work has demonstrated distinct lipid imbalances in multiple model systems either depleted for or devoid of the TANGO2 ...

Article GUID: 38836374


Vitamin B5, a Coenzyme A precursor, rescues TANGO2 deficiency disease-associated defects in Drosophila and human cells

Author(s): Asadi P; Milev MP; Saint-Dic D; Gamberi C; Sacher M;

Mutations in the Transport and Golgi Organization 2 (TANGO2) gene are associated with intellectual deficit, neurodevelopmental delay and regression. Individuals can also present with an acute metabolic crisis that includes rhabdomyolysis, cardiomyopathy and cardiac arrhythmias, the latter of which are potentially lethal. While preventing metabolic crises ...

Article GUID: 36502486


Empowering Melatonin Therapeutics with Drosophila Models

Author(s): Millet-Boureima C; Ennis CC; Jamison J; McSweeney S; Park A; Gamberi C;

Melatonin functions as a central regulator of cell and organismal function as well as a neurohormone involved in several processes, e.g., the regulation of the circadian rhythm, sleep, aging, oxidative response, and more. As such, it holds immense pharmacological potential. Receptor-mediated melatonin function mainly occurs through MT1 and MT2, conserved ...

Article GUID: 34698120


Cyst Reduction by Melatonin in a Novel Drosophila Model of Polycystic Kidney Disease.

Author(s): Millet-Boureima C; Rozencwaig R; Polyak F; Gamberi C;

Autosomal dominant polycystic kidney disease (ADPKD) causes progressive cystic degeneration of the renal tubules, the nephrons, eventually severely compromising kidney function. ADPKD is incurable, with half of the patients eventually needing renal replacement. Treatments for ADPKD patients are limited and new effective therapeutics are needed. Melatonin, ...

Article GUID: 33238462


Drug discovery and chemical probing in Drosophila.

Author(s): Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Genome. 2020 Jun 18;: Authors: Millet-Boureima C, Selber-Hnatiw S, Gamberi C

Article GUID: 32551911


Editorial: RNA Regulation in Development and Disease.

Author(s): Chartrand P, Jaramillo M, Gamberi C

Front Genet. 2020;11:430 Authors: Chartrand P, Jaramillo M, Gamberi C PMID: 32411184 [PubMed]

Article GUID: 32411184


Cyst Reduction in a Polycystic Kidney Disease Drosophila Model Using Smac Mimics.

Author(s): Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Biomedicines. 2019 Oct 18;7(4): Authors: Millet-Boureima C, Chingle R, Lubell WD, Gamberi C

Article GUID: 31635379


Modeling Renal Disease "On the Fly".

Author(s): Millet-Boureima C, Porras Marroquin J, Gamberi C

Biomed Res Int. 2018;2018:5697436 Authors: Millet-Boureima C, Porras Marroquin J, Gamberi C

Article GUID: 29955604


Mapping the fly Malpighian tubule lipidome by imaging mass spectrometry

Author(s): Yang E; Gamberi C; Chaurand P;

Matrix-assisted laser/desorption ionization imaging mass spectrometry (MALDI IMS) is an analytical technique for understanding the spatial distribution of biomolecules across a sample surface. Originally employed for mammalian tissues, this technology has been adapted to study specimens as diverse as microbes and cell cultures, food such as strawberries, ...

Article GUID: 31038251


-   Page 1 / 1   -