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Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner

Author(s): de Zavalia N; Schoettner K; Goldsmith JA; Solis P; Ferraro S; Parent G; Amir S;

Alcohol consumption has been strongly associated with circadian clock gene expression in mammals. Analysis of clock genes revealed a potential role of Bmal1 in the control of alcohol drinking behavior. However, a causal role of Bmal1 and neural pathways through which it may influence alcohol intake have not yet been established. Here we show that selectiv ...

Article GUID: 34702951


In utero Exposure to Valproic-Acid Alters Circadian Organisation and Clock-Gene Expression: Implications for Autism Spectrum Disorders

Author(s): Ferraro S; de Zavalia N; Belforte N; Amir S;

Autism Spectrum Disorder (ASD) is a pervasive neurodevelopmental disorder characterised by restrictive patterns of behaviour and alterations in social interaction and communication. Up to 80% of children with ASD exhibit sleep-wake cycle disturbances, emphasising the pressing need for novel approaches in the treatment of ASD-associated comorbidities. Whil ...

Article GUID: 34650409


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