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Pitavastatin Calcium Confers Fungicidal Properties to Fluconazole by Inhibiting Ubiquinone Biosynthesis and Generating Reactive Oxygen Species

Author(s): Li W; Feng Y; Feng Z; Wang L; Whiteway M; Lu H; Jiang Y;

Fluconazole (FLC) is extensively employed for the prophylaxis and treatment of invasive fungal infections (IFIs). However, the fungistatic nature of FLC renders pathogenic fungi capable of developing tolerance towards it. Consequently, converting FLC into a fungicidal agent using adjuvants assumes significance to circumvent FLC resistance and the perpetua ...

Article GUID: 38929106


Refined design of ventilation systems to mitigate infection risk in hospital wards: Perspective from ventilation openings setting

Author(s): Ren C; Wang J; Feng Z; Kim MK; Haghighat F; Cao SJ;

To prevent respiratory infections between patients and medical workers, the transmission risk of airborne pollutants in hospital wards must be mitigated. The ventilation modes, which are regarded as an important strategy to minimize the infection risk, is challenging to systematically design. Studies have considered the effect of ventilation openings (inl ...

Article GUID: 37336354


Intelligent operation, maintenance, and control system for public building: Towards infection risk mitigation and energy efficiency

Author(s): Ren C; Zhu HC; Wang J; Feng Z; Chen G; Haghighat F; Cao SJ;

During the post-COVID-19 era, it is important but challenging to synchronously mitigate the infection risk and optimize the energy savings in public buildings. While, ineffective control of ventilation and purification systems can result in increased energy consumption and cross-contamination. This paper is to develop intelligent operation, maintenance, a ...

Article GUID: 36941886


Impact of ionizers on prevention of airborne infection in classroom

Author(s): Ren C; Haghighat F; Feng Z; Kumar P; Cao SJ;

Infectious diseases (e.g., coronavirus disease 2019) dramatically impact human life, economy and social development. Exploring the low-cost and energy-saving approaches is essential in removing infectious virus particles from indoors, such as in classrooms. The application of air purification devices, such as negative ion generators (ionizers), gains popu ...

Article GUID: 36474607


Removal of SARS-CoV-2 using UV+Filter in built environment: simulation/evaluation by utilizing validated numerical method

Author(s): Feng Z; Cao SJ; Haghighat F;

Air cleaning is an effective and reliable method in indoor airborne SARS-CoV-2 (Severe Acute Respiratory Syndrome Corona-Virus 2) control, with ability of aerosol removal or disinfection. However, traditional air cleaning systems (e.g. fibrous filter, electrostatic removal system) have some risks in operation process, including re-aerosolization and elect ...

Article GUID: 34367884


Mitigating COVID-19 infection disease transmission in indoor environment using physical barriers

Author(s): Ren C; Xi C; Wang J; Feng Z; Nasiri F; Cao SJ; Haghighat F;

During the normalized phase of COVID-19, droplets or aerosol particles produced by infected personnel are considered as the potential source of infection with uncertain exposure risk. As such, in densely populated open spaces, it is necessary to adopt strategies to mitigate the risk of infection disease transmission while providing sufficient ventilation ...

Article GUID: 34306996


Indoor airborne disinfection with electrostatic disinfector (ESD): Numerical simulations of ESD performance and reduction of computing time

Author(s): Feng Z; Cao SJ; Wang J; Kumar P; Haghighat F;

Airborne transmissions of infectious disease (e.g. SARS-CoV-2) in indoor environments may induce serious threat to public health. Air purification devices are necessary to remove and/or inactivate airborne biological species from indoor air environment. Corona discharge in an electrostatic precipitator is capable of removing particulate matter and disinfe ...

Article GUID: 33994653


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