PERFORM Publications

The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks

Author(s): Alvarez MR; Alkaissi H; Rieger AM; Esber GR; Acosta ME; Stephenson SI; Maurice AV; Valencia LMR; Roman CA; Alarcon JM;

Stimulation of the inflammatory reflex (IR) is a promising strategy for treating systemic inflammatory disorders. Recent studies suggest oral sodium bicarbonate (NaHCO3) as a potential activator of the IR, offering a safe and cost-effective treatment approach. However, the mechanisms underlying N ...

Article GUID: 38549144

OFC neurons do not represent the negative value of a conditioned inhibitor

Author(s): Esber GR; Usypchuk A; Saini S; Deroche M; Iordanova MD; Schoenbaum G;

The orbitofrontal cortex (OFC) is often proposed to function as a value integrator; however, alternative accounts focus on its role in representing associative structures that specify the probability and sensory identity of future outcomes. These two accounts make different predictions about how this area should respond to conditioned inhibitors of reward ...

Article GUID: 38042330

The Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala During the First Extinction Episode Has Persistent Effects on Extinction Expression

Author(s): Lay BPP; Koya E; Hope BT; Esber GR; Iordanova MD;

Background: Adaptive behavior depends on the delicate and dynamic balance between acquisition and extinction memories. Disruption of this balance, particularly when the extinction of memory loses control over behavior, is the root of treatment failure of maladaptive behaviors such as substance abuse or anxiety disorders. Understanding this balance require ...

Article GUID: 36336498

Correction to: Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

No abstract

Article GUID: 36006415

Experimental chambers Persistent disruption of overexpectation learning after inactivation of the lateral orbitofrontal cortex in male rats

Author(s): Lay BPP; Choudhury R; Esber GR; Iordanova MD;

Rationale and objective: Learning to inhibit acquired fear responses is fundamental to adaptive behavior. Two procedures that support such learning are extinction and overexpectation. In extinction, an expected outcome is omitted, whereas in overexpectation two individually trained cues are presented in compound to induce an expectation of a greater outco ...

Article GUID: 35932299

Agency rescues competition for credit assignment among predictive cues from adverse learning conditions

Author(s): Kang M; Reverte I; Volz S; Kaufman K; Fevola S; Matarazzo A; Alhazmi FH; Marquez I; Iordanova MD; Esber GR;

A fundamental assumption of learning theories is that the credit assigned to predictive cues is not simply determined by their probability of reinforcement, but by their ability to compete with other cues present during learning. This assumption has guided behavioral and neural science research f ...

Article GUID: 34376741

Different methods of fear reduction are supported by distinct cortical substrates.

Author(s): Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD

Elife. 2020 Jun 26;9: Authors: Lay BP, Pitaru AA, Boulianne N, Esber GR, Iordanova MD

Article GUID: 32589138

A self-initiated cue-reward learning procedure for neural recording in rodents.

Author(s): Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

J Neurosci Methods. 2020 Mar 02;:108671 Authors: Reverte I, Volz S, Alhazmi FH, Kang M, Kaufman K, Chan S, Jou C, Iordanova MD, Esber GR

Article GUID: 32135212

Neural correlates of two different types of extinction learning in the amygdala central nucleus.

Author(s): Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Nat Commun. 2016 08 17;7:12330 Authors: Iordanova MD, Deroche ML, Esber GR, Schoenbaum G

Article GUID: 27531638

Dissociation of Appetitive Overexpectation and Extinction in the Infralimic Cortex.

Author(s): Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Cereb Cortex. 2018 Oct 29;: Authors: Lay BPP, Nicolosi M, Usypchuk AA, Esber GR, Iordanova MD

Article GUID: 30371757

Corrigendum: Dissociation of Appetitive Overexpectation and Extinction in the Infralimbic Cortex.