Author(s): Darwish A; Papolla C; Rieu R; Kadem L;

In vitro modeling of the left heart relies on accurately replicating the physiological conditions of the native heart. The targeted physiological conditions include the complex fluid dynamics coming along with the opening and closing of the aortic and mitral valves. As the mitral valve possess a highly sophisticated apparatus, thence, accurately modeling ...

Article GUID: 38228812

Author(s): Darwish A; Norouzi S; Kadem L;

Purpose: Identification of coherent structures in cardiovascular flows is crucial to describe the transport and mixing of blood. Coherent structures can highlight locations where minimal blood mixing takes place, thus, potential thrombus formation can be expected thither. Graph-based approaches have recently been introduced in order to describe fluid tran ...

Article GUID: 34845627

Author(s): Wiener PC, Darwish A, Friend E, Kadem L, Pressman GS

INTRODUCTION: Study aims were to compare hemodynamics and viscous energy dissipation (VED) in 3D printed mitral valves-one replicating a normal valve and the other a valve with severe mitral annular calcification (MAC). Patients with severe MAC develop transmitral gradients, without the commissural fusion typifying rheumatic mitral stenosis (MS), and may ...

Article GUID: 33591991

Author(s): Darwish A, Di Labbio G, Saleh W, Kadem L

PURPOSE: Aortic valve replacement remains the only viable solution for symptomatic patients with severe aortic valve stenosis. Despite their improved design and long history of successful operation, bileaflet mechanical heart valves are still associated with post-operative complications leading to valve dysfunction. Thus, the flow dynamics can be highly d ...

Article GUID: 33469847

Author(s): Papolla C, Darwish A, Kadem L, Rieu R

PURPOSE: Mitral regurgitation (MR) is the second most common valve disease in industrialized countries. Despite its high prevalence, little is known about its impact on the flow dynamics in the left ventricle (LV). Because of the interdependence between valvular function and hemodynamics in the heart chambers, an exploration of the dynamics in the LV coul ...

Article GUID: 33000444

Author(s): Darwish A, Di Labbio G, Saleh W, Smadi O, Kadem L

Artif Organs. 2019 May 08;: Authors: Darwish A, Di Labbio G, Saleh W, Smadi O, Kadem L

Article GUID: 31066923