1 Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada.
2 Department of Biology, Concordia University, Montreal, Quebec H4B 1R6, Canada, vladimir.titorenko@concordia.ca.

Lipid metabolism and transport define longevity of the yeast Saccharomyces cerevisiae.

Front Biosci (Landmark Ed). 2018 Jan 01;23:1166-1194

Authors: Mitrofanova D, Dakik P, McAuley M, Medkour Y, Mohammad K, Titorenko VI

Abstract

Emergent evidence indicates that certain aspects of lipid synthesis, degradation and interorganellar transport play essential roles in modulating the pace of cellular aging in the budding yeast Saccharomyces cerevisiae. The molecular mechanisms underlying the vital roles of lipid metabolism and transport in defining yeast longevity have begun to emerge. The scope of this review is to critically analyze recent progress in understanding such mechanisms.

PMID: 28930594 [PubMed - indexed for MEDLINE]