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Mesocorticolimbic function in cocaine polydrug users: A multimodal study of drug cue reactivity and cognitive regulation

Author(s): Scala SG; Kang MS; Cox SML; Rosa-Neto P; Massarweh G; Leyton M;

Addictions are thought to be fostered by the emergence of poorly regulated mesocorticolimbic responses to drug-related cues. The development and persistence of these responses might be promoted by altered glutamate transmission, including changes to type 5 metabotropic glutamate receptors (mGluR5s). Unknown, however, is when these changes arise and whethe ...

Article GUID: 38221806


Cocaine cue-induced mesocorticolimbic activation in cocaine users: Effects of personality traits, lifetime drug use, and acute stimulant ingestion

Author(s): D' Amour-Horvat V; Cox SML; Dagher A; Kolivakis T; Jaworska N; Leyton M;

Stimulant drug-paired cues can acquire the ability to activate mesocorticolimbic pathways and lead to new bouts of drug use. Studies in laboratory animals suggest that these effects are augmented by progressively greater drug use histories, impulsive personality traits, and acute drug ingestion. As a preliminary test of these hypotheses in humans, we expo ...

Article GUID: 34463411


mGlu5 receptor availability in youth at risk for addictions: effects of vulnerability traits and cannabis use.

Author(s): Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M

Neuropsychopharmacology. 2020 May 15;: Authors: Cox SML, Tippler M, Jaworska N, Smart K, Castellanos-Ryan N, Durand F, Allard D, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté S, Tremblay RE, Séguin JR, Leyton M

Article GUID: 32413893


Extra-striatal D2/3 receptor availability in youth at risk for addiction.

Author(s): Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M

Neuropsychopharmacology. 2020 Apr 07;: Authors: Jaworska N, Cox SML, Tippler M, Castellanos-Ryan N, Benkelfat C, Parent S, Dagher A, Vitaro F, Boivin M, Pihl RO, Côté SM, Tremblay RE, Séguin JR, Leyton M

Article GUID: 32259831


Effect of (Z)-isomer content on [11C]ABP688 binding potential in humans.

Author(s): Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1175-1178 Authors: Smart K, Cox SML, Kostikov A, Shalai A, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Article GUID: 30607444


Sex differences in [11C]ABP688 binding: a positron emission tomography study of mGlu5 receptors.

Author(s): Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Eur J Nucl Med Mol Imaging. 2019 May;46(5):1179-1183 Authors: Smart K, Cox SML, Scala SG, Tippler M, Jaworska N, Boivin M, Séguin JR, Benkelfat C, Leyton M

Article GUID: 30627817


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