Author(s): Olajide OJ; Batallán Burrowes AA; da Silva IF; Bergdahl A; Chapman CA;
Reductions in circulating estrogens can contribute to cognitive decline, in part by impairing mitochondrial function within the hippocampal region. The entorhinal cortex provides the hippocampus with its main cortical input and, to assess the impact of estrogen deficiency on mitochondrial respiration and synaptic proteins in the entorhinal cortex, wildtyp ...
Article GUID: 39617168
Author(s): Batallán Burrowes AA; Moisan É; Garrone A; Buynack LM; Chapman CA;
Estrogens are believed to modulate cognitive functions in part through the modulation of synaptic transmission in the cortex and hippocampus. Administration of 17ß-estradiol (E2) can rapidly enhance excitatory synaptic transmission in the hippocampus and facilitate excitatory synaptic transmission in rat lateral entorhinal cortex via activation of the G p ...
Article GUID: 39150316
Author(s): Olajide OJ; La Rue C; Bergdahl A; Chapman CA;
Increasing evidence suggests that mitochondrial dysfunction and aberrant release of mitochondrial reactive oxygen species (ROS) play crucial roles in early synaptic perturbations and neuropathology that drive memory deficits in Alzheimer's disease (AD). We recently showed that solubilized human amyloid beta peptide 1-42 (hAß1-42) causes rapid alterati ...
Article GUID: 36275011
Author(s): Batallán Burrowes AA; Olajide OJ; Iasenza IA; Shams WM; Carter F; Chapman CA;
Estrogens are thought to contribute to cognitive function in part by promoting the function of basal forebrain cholinergic neurons that project to the hippocampus and cortical regions including the entorhinal cortex. Reductions in estrogens may alter cognition by reducing the function of cholinergic inputs to both the hippocampus and entorhinal cortex. In ...
Article GUID: 35939438
Author(s): Batallán Burrowes AA; Sundarakrishnan A; Bouhour C; Chapman CA;
Activation of estrogen receptors is thought to modulate cognitive function in the hippocampus, prefrontal cortex, and striatum by affecting both excitatory and inhibitory synaptic transmission. The entorhinal cortex is a major source of cortical sensory and associational input to the hippocampus, but it is unclear whether either estrogens or progestogens ...
Article GUID: 34399010
Author(s): Olajide OJ; Chapman CA;
The hippocampus and entorhinal cortex (EC) accumulate amyloid beta peptides (Aß) that promote neuropathology in Alzheimer's disease, but the early effects of Aß on excitatory synaptic transmission in the EC have not been well characterized. To assess the acute effects of Aß1-42 on glutamatergic synapses, acute brain slices from wildtype rats were expo ...
Article GUID: 34144329
Author(s): Olajide OJ, Suvanto ME, Chapman CA
The entorhinal cortex (EC) is a vital component of the medial temporal lobe, and its contributions to cognitive processes and memory formation are supported through its extensive interconnections with the hippocampal formation. During the pathogenesis of Alzheimer's disease (AD), many of the earliest degenerative changes are seen within the EC. Neurod ...
Article GUID: 33495355
Author(s): Tremblay SA, Chapman CA, Courtemanche R
Front Syst Neurosci. 2019;13:60 Authors: Tremblay SA, Chapman CA, Courtemanche R
Article GUID: 31736718
Author(s): Sparks DW, Chapman CA
J Neurophysiol. 2016 08 01;116(2):658-70 Authors: Sparks DW, Chapman CA
Article GUID: 27146979
Author(s): Robinson JC, Chapman CA, Courtemanche R
Cerebellum. 2017 08;16(4):802-811 Authors: Robinson JC, Chapman CA, Courtemanche R
Article GUID: 28421552
Author(s): Hutter JA, Chapman CA
Behav Brain Funct. 2013 Oct 04;9:37 Authors: Hutter JA, Chapman CA
Article GUID: 24093833
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