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Biological sex and bilingualism: Its impact on risk and resilience for dementia

Author(s): Calvo N; Phillips N; Bialystok E; Einstein G;

Introduction: The relationship between biological sex, considered a risk factor for Alzheimer's disease (AD), and bilingualism, a resilience factor, is unclear. We assessed this relationship in 335 individuals with mild cognitive impairment (MCI) in a Canadian cohort. Methods: We used univariate analysis and structural equation modelling to study the ...

Article GUID: 41573422


Clinical Manifestations

Author(s): Calvo N; Siddiqui R; Phillips N; Einstein G;

Background: Globally, females are at twice the risk of AD than males; in Canada, over 700,000 are living with Alzheimer's disease and related dementia (ADRDs), with 72% being female. However, females maintain verbal memory in the face of more AD pathology than men. It is unclear how multilingualism, considered a resilience factor, might interact with ...

Article GUID: 39750698


Effects of early midlife ovarian removal on sleep: Polysomnography-measured cortical arousal, homeostatic drive, and spindle characteristics

Author(s): Brown A; Gervais NJ; Gravelsins L; O' Byrne J; Calvo N; Ramana S; Shao Z; Bernardini M; Jacobson M; Rajah MN; Einstein G;

Bilateral salpingo-oophorectomy (BSO; removal of ovaries and fallopian tubes) prior to age 48 is associated with elevated risk for both Alzheimer's disease (AD) and sleep disorders such as insomnia and sleep apnea. In early midlife, individuals with BSO show reduced hippocampal volume, functi ...

Article GUID: 39178647


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