1 Centre for Research in Human Development, Department of Psychology, Concordia University, Montreal, QC, Canada.
2 Department of Neuroscience, Carleton University, Ottawa, ON, Canada; Institute of Mental Health Research, Royal Ottawa Mental Health Centre, Ottawa, ON, Canada. Electronic address: christopher.cardoso@gmail.com.

A meta-analytic review of the correlation between peripheral oxytocin and cortisol concentrations.

Front Neuroendocrinol. 2016 10;43:19-27

Authors: Brown CA, Cardoso C, Ellenbogen MA

Abstract

The stress dampening effects of exogenous oxytocin in humans have been well documented. However, the relation between endogenous oxytocin and cortisol is poorly understood. We conducted a meta-analysis on the correlation between oxytocin and cortisol levels measured at baseline (k=24, N=739). The effect size for the baseline correlation statistic was small (Pearson r=0.163, p=0.008), with high heterogeneity (I2=67.88%). Moderation analysis revealed that studies where participants anticipated an experimental manipulation evidenced a greater positive correlation compared to those that did not (Pearson r=0.318, p=0.006). A supplementary analysis including additional studies indicated that oxytocin levels in unextracted samples were 60 times higher when using this questionable practice. The findings suggest that the interplay between oxytocin and cortisol is dynamic and sensitive to the anticipation of stress or novelty. Furthermore, extraction of oxytocin appears to be an essential methodological practice.

PMID: 27836673 [PubMed - indexed for MEDLINE]