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Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy

Author(s): Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivière S; Caciagli L; Pana R; Weil AG; Grova C; Frauscher B; Schrader DV; Zhang Z; Concha L; Bernasc ...

Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 d ...

Article GUID: 41258102


The BigBrainWarp toolbox for integration of BigBrain 3D histology with multimodal neuroimaging

Author(s): Paquola C; Royer J; Lewis LB; Lepage C; Glatard T; Wagstyl K; DeKraker J; Toussaint PJ; Valk SL; Collins DL; Khan A; Amunts K; Evans AC; Dickscheid T; Bernhardt BC;

Neuroimaging stands to benefit from emerging ultrahigh-resolution 3D histological atlases of the human brain; the first of which is 'BigBrain'. Here, we review recent methodological advances for the integration of BigBrain with multi-modal neuroimaging and introduce a toolbox, 'BigBra ...

Article GUID: 34431476


Cortical gradients of functional connectivity are robust to state-dependent changes following sleep deprivation.

Author(s): Cross N; Paquola C; Pomares FB; Perrault AA; Jegou A; Nguyen A; Aydin U; Bernhardt BC; Grova C; Dang-Vu TT;

Sleep deprivation leads to significant impairments in cognitive performance and changes to the interactions between large scale cortical networks, yet the hierarchical organisation of cortical activity across states is still being explored. We used functional magnetic resonance imaging to assess ...

Article GUID: 33186718


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