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Transcriptomics identify the triggering of citrate export as the key event caused by manganese deficiency in Aspergillus niger

Author(s): Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Sándor E; Kovács B; Geoffrion N; Tsang A; Kubicek CP; Karaffa L;

For over a century, the filamentous Ascomycete fungus Aspergillus niger has played a pivotal role in the industrial production of citric acid. A critical fermentation parameter that sustains high-yield citric acid accumulation is the suboptimal concentration of manganese(II) ions in the culture b ...

Article GUID: 39377610


Bioreactor as the root cause of the "manganese effect" during Aspergillus niger citric acid fermentations

Author(s): Fekete E; Bíró V; Márton A; Bakondi-Kovács I; Németh Z; Sándor E; Kovács B; Fábián I; Kubicek CP; Tsang A; Karaffa L;

High-yield citric acid production by the filamentous Ascomycete fungus Aspergillus niger requires a combination of extreme nutritional conditions, of which maintaining a low manganese (II) ion concentration (-1) is a key feature. Technical-scale production of citric acid predominantly uses stainl ...

Article GUID: 35992333


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