Author(s): Taktikakis P; Côté M; Subramaniam N; Kroeger K; Youssef H; Badia A; DeWolf C;

Deviations from the normal physicochemical and functional properties of pulmonary surfactants are associated with the incidence of lung injury and other respiratory disorders. This study aims to evaluate the alteration of the 2D molecular organization and morphology of pulmonary surfactant model membranes by the electronic cigarette additives a-tocopherol ...

Article GUID: 38437623

Author(s): Ali DA; Domínguez Mercado L; Findlay BL; Badia A; DeWolf C;

Antimicrobial peptides, such as GL13K, have a high binding selectivity toward bacterial membranes, while not affecting healthy mammalian cells at therapeutic concentrations. However, delivery of these peptides is challenging since they are susceptible to proteolytic hydrolysis and exhibit poor cellular uptake. A protective nanocarrier is thus proposed to ...

Article GUID: 36525622

Author(s): Gravel-Tatta L; DeWolf C; Badia A;

Nanoparticle carriers show promise for drug delivery, including by inhalation, where the first barrier for uptake in the lungs is the monolayer pulmonary surfactant membrane that coats the air/alveoli interface and is critical to breathing. It is imperative to establish the fate of potential nanocarriers and their effects on the biophysical properties of ...

Article GUID: 34644076