Author(s): Jobin B; Frasnelli J; Phillips NA; Boller B;

Background: Olfactory identification is impaired early in the clinical continuum of Alzheimer's disease (AD) and is already observable in mild cognitive impairment (MCI). A recent meta-analysis showed significant associations between olfactory identification and episodic memory scores in older adults without cognitive impairment. Thus, olfactory ident ...

Article GUID: 41443638

Author(s): Grant N; Phillips NA;

Background: Age-related hearing loss (HL) is associated with poorer cognition and increased risk of developing dementia. However, few studies have explored if sex affects the association between HL and cognition. We investigated the relationship between two hearing measures and performance on cognitive screening and neuropsychological tests in males and f ...

Article GUID: 41443651

Author(s): Kouzoukas E; Navas C; Zawertailo L; Fougere C; Bacon SL; Chadi N; Evans WK; McNeill A; Melamed O; Moraes TJ; Nnorom O; Schwartz R; Shahab L; Ween M; Selby P;

Objective: To develop evidence-informed recommendations on the health effects of e-cigarettes to guide healthcare practitioners and the public to balance individual and population harm reduction. Methods: Systematic and umbrella reviews investigating the health effects of e-cigarette use were co ...

Article GUID: 41443121

Author(s): Silva NCBS; Stein RG; Gu Y; Hsu CL; Tam RC; Salluzzi M; McCreary CR; Alkeridy WA; Lam K; MacKay AL; Kolind S; Cossette B; Griffith LE; Hogan DB; McMillan JM; Raina P; Smith EE; Liu-Ambrose T;

Background: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of COVID-19 and has infected >700 million persons worldwide. Individuals infected with SARS-CoV-2 are at risk for cognitive decline and at higher risk of dementia compared with those diagnosed with oth ...

Article GUID: 41434542

Author(s): Silva NCBS; Balbim GM; Stein RG; Gu Y; Tam RC; Dao E; Alkeridy WA; Kramer AF; Liu-Ambrose T;

Background: Physical activity is associated with higher myelin content in older individuals with cerebral small vessel disease (CSVD), a condition marked by demyelination. However, potential mechanisms underlying these associations remain understudied. High-density lipoprotein (HDL) is involved i ...

Article GUID: 41435075

Author(s): Borrie MJ; Phillips NA; Best S; Anastasiou-Ventura P; Aydogan T; Beaudoin C; Beuk J; Celotto I; Cole L; Das S; Fogarty J; Fouquet C; Gnassi L; Henri-Bellemare C; Pilon R; Sands J; Stirbu A; Truemner J; Chan S; Tucker A; Gajraj J; Bhangu ...

Background: The Comprehensive Assessment of Neurodegeneration and Dementia (COMPASS-ND) used wide inclusion criteria recruiting participants across the spectrum from normal cognition to cognitive impairment to all types of clinical dementia, including mixed dementia. 1173 participants comprising ...

Article GUID: 41435411

Author(s): Mitchell SW; Chan T; Trudel L; Hosseini SA; Macedo AC; Gonçalves MP; Rahmouni N; Hall BJ; Socualaya KMQ; Therriault J; Servaes S; Bezgin G; Zheng Y; Aumont E; Wang YT; Arias JF; Real APB; Jia WL; Hopewell R; Hsiao C; Soucy JP; Vitali P; ...

Background: Brain and cognitive resilience (BR, CR) reflect the capacity to maintain structural integrity and cognitive function despite pathological tau deposition in Alzheimer's disease (AD). Tau pathology can be characterized in terms of spatial extent of tauopathy (SEOT) or load using sta ...

Article GUID: 41433447

Author(s): Gurve D; Centen AP; Slack PJ; Dang-Vu TT; Belleville S; Anderson ND; Montero-Odasso M; Nygaard HB; Chertkow H; Feldman HH; Brewster PWH; Lim A;

Background: Older adults experience considerable day-to-day variability in cognitive function. We aimed to test the hypothesis that this is in part related to sleep, and determine which EEG sleep features are most important in supporting day to day cognitive resilience. Method: We analyzed data ...

Article GUID: 41434309

Author(s): Lamontagne-Kam D; Rahimabadi A; Bello DG; Lavallée-Beaulieu M; Fermawi AE; Bonenfant L; Nanci A; Benali H; Brouillette J;

Background: Tau pathology is an important neuropathological marker of Alzheimer's Disease (AD) and correlates closely with neurodegeneration and cognitive decline. To date, much of the work examining tau propagation has been performed using mutated tau and/or transgenic animal models. Since t ...

Article GUID: 41435278

Author(s): Morrison K; Pottier P; Pollo P; Ricolfi L; Williams C; Yang Y; Beillouin D; Cardoso SJ; Ferreira V; Gallagher B; Gan JL; Hao G; Keikha M; Kozlowsky-Suzuki B; Kiran Kumara TM; Latterini F; Leverkus AB; Macartney EL; Manrique SM; Martinig ...

Meta-analysis is commonly a core component of systematic reviews and has become an important method to reconcile conflicting findings, increase statistical power, and chart new research directions. However, poor reporting practices make it challenging to evaluate the validity of meta-analyses. De ...

Article GUID: 41411971

Author(s): Joly-Smith E; Talpur MM; Allard P; Papazotos F; Potvin-Trottier L; Hilfinger A;

Characterizing and manipulating cellular behavior requires a mechanistic understanding of the causal interactions between cellular components. We present an approach to detect causal interactions between genes without the need to perturb the physiological state of cells. This approach exploits naturally occurring cell-to-cell variability which is experime ...

Article GUID: 41401079