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ADPv2: A hierarchical histological tissue type-annotated dataset for potential biomarker discovery of colorectal disease

Author(s): Yang Z; Li K; Ramandi SG; Brassard P; Khellaf A; Trinh VQ; Zhang J; Chen L; Rowsell C; Varma S; Plataniotis K; Hosseini MS;

Computational pathology (CPath) leverages histopathology images to enhance diagnostic precision and reproducibility in clinical pathology. However, publicly available datasets for CPath that are annotated with extensive histological tissue type (HTT) taxonomies at a granular level remain scarce d ...

Article GUID: 41658283


Tuned to walk: cue type, beat perception, and gait dynamics during rhythmic stimulation in aging

Author(s): Parker A; Dalla Bella S; Penhune VB; Young L; Grenet D; Li KZH;

Rhythmic auditory cueing (RAC) improves spatiotemporal gait parameters in older adults, often using isochronous rhythmic cues (i.e., with constant inter-beat-intervals). However, healthy gait contains fractal-like variability, (i.e., with persistent long-range correlations; LRC) which is disturbed when walking to isochronous cues. Embedding auditory cues ...

Article GUID: 41661338


The prevalence and predictors of aggressive obsessions in obsessive-compulsive disorder: A meta-analytic review

Author(s): Fawcett EJ; Morris Q; Lahey C; Corran C; Krause S; Bishop OC; Rash JA; Carter J; Fawcett JM;

Obsessive-compulsive disorder (OCD) is a heterogeneous condition often characterized in relation to major symptom dimensions, including contamination, symmetry/exactness, religious, aggressive, sexual, hoarding/saving, somatic, and miscellaneous. Aggressive obsessions, defined as intrusive though ...

Article GUID: 41650656


A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

Author(s): McCallum G; Burckhardt JC; He J; Hong A; Potvin-Trottier L; Tropini C;

The human gut is a dynamic environment, where changes in pH, oxygen, and osmolality influence microbiota composition and disease. Monitoring these environmental shifts is crucial for advancing gut health diagnostics and therapeutics, yet non-invasive monitoring tools remain limited. Genetically tractable commensals, including Bacteroides thetaiotaomicron, ...

Article GUID: 41610848


Impact of COVID-19 on incidence and trends of adverse events among hospitalised patients in Calgary, Canada: a retrospective chart review study

Author(s): Wu G; Eastwood CA; Cheligeer C; Southern DA; Zeng Y; Ghali WA; Bakal JA; Boussat B; Flemons W; Forster A; Xu Y; Quan H;

Background: While the incidence of hospital adverse events appeared to be declining before 2019, the COVID-19 pandemic may have changed its course. This study aimed to evaluate adverse event incidence rates and trends during the pandemic and analyse differences in patient outcomes. Methods: This ...

Article GUID: 41592994


Organic chemicals of Arctic concern in Russian coastal seas

Author(s): Min XZ; Zhang X; Xie ZY; Nikolaev A; Vorkamp K; Ma JM; Reiersen LO; Li L; Cai MH; Ren NQ; Li YF; Zhang ZF; Kallenborn R; Muir D;

Arctic ecosystems face significant threats from chemicals of global concern. Persistent organic pollutants (POPs) and polycyclic aromatic hydrocarbons (PAHs) have been consistently detected in the Arctic through decades of monitoring. POPs are known to bioaccumulate in food webs, and both POPs an ...

Article GUID: 41571477


Divergent creativity in humans and large language models

Author(s): Bellemare-Pepin A; Lespinasse F; Thölke P; Harel Y; Mathewson K; Olson JA; Bengio Y; Jerbi K;

The recent surge of Large Language Models (LLMs) has led to claims that they are approaching a level of creativity akin to human capabilities. This idea has sparked a blend of excitement and apprehension. However, a critical piece that has been missing in this discourse is a systematic evaluation ...

Article GUID: 41565675


5 weeks of online resistance training with blood flow restriction increases sit-to-stand oxygen consumption in healthy older adults

Author(s): Presta D; Bergdahl A;

Maximal oxygen consumption (VO2 max) reflects the greatest amount of oxygen utilized upon exertion. Blood flow restriction (BFR) limits venous return, enabling low-intensity exercise to yield adaptations like high-intensity training. This study examined whether 5 weeks of online resistance training (RT) with BFR straps improves VO2, tidal volume, and resp ...

Article GUID: 41565628


Genetic dissection of stool frequency implicates vitamin B1 metabolism and other actionable pathways in the modulation of gut motility

Author(s): Díaz-Muñoz C; Bozzarelli I; Lopera-Maya EA; Belbasis L; Lo Faro V; Camargo Tavares L; Heredia-Fernández F; Di Lorenzo B; Sinha T; Esteban Blanco C; Favé MJ; Awadalla P; Walters RG; Bonfiglio F; Zhernakova A; Sanna S; D' Amato M;

Background: Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. Objective: To identify genes and mechanisms involved in gut motility, providing a foundation for cli ...

Article GUID: 41558814


Scientists warning: we must change paradigm for a revolution in toxicology and world food supply

Author(s): Seralini GE; Jungers G; Andersen A; Antoniou M; Aschner M; Bacon MH; Bertrand M; Bohn T; Bonfleur ML; Bücking E; Defarge N; Djemil R; Domingo JL; Douzelet J; Fagan J; Fournier T; Garcia JLY; Gil S; Hervé-Gruyer P; Hilbeck A; Hilty L; Hub ...

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petr ...

Article GUID: 41551494


The effect of 14 days Actovegin administration with or without high intensity training on exercise capacity and skeletal muscle mitochondrial respiration

Author(s): Hassø RK; Lindtofte S; Kosik B; Bergdahl A; Larsen S;

Article GUID: 41553522


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