Author(s): Plissonneau C; Tam BT; Garneau PY; Morais JA; Piekny A; Santosa S;

Transwell co-culture systems are models for examining cellular crosstalk, but the impact of porous membrane material on myogenic outcomes remains uncharacterized. We investigated the influence of transwell membrane material on myoblast differentiation in co-culture with human primary adipocytes and in varying concentrations of insulin-transferrin-selenium ...

Article GUID: 42260998

Author(s): MacPherson A; Caizergues AE; Savary P; Xu K; Messer PW; Akbar MN; Fortin MJ; Holt RD; Hoi AG; Mideo N; Ness R; Peres-Neto PR; Santangelo JS; Johnson MTJ;

Urbanization drives rapid and extreme environmental change, profoundly shaping the ecology and evolution of populations. In this Perspective, we call for the integration and development of evolutionary theory and empirical research through collaboration between theoretical and experimental biolog ...

Article GUID: 42253486

Author(s): Delaney KZ; Nadeem MI; Plissonneau C; Khor N; Delaney J; Morais JA; Tsoukas MA; Pescarus R; Garneau PY; Santosa S;

Adipose tissue (AT) immune cells are implicated in the pathology of type 2 diabetes (T2D), and their content likely differs between abdominal subcutaneous adipose tissue (abSAT), femoral SAT (fmSAT), and visceral adipose tissue (VAT). Therefore, the objective of the current study was to develop a ...

Article GUID: 42255513

Author(s): Fortin M; Chauhan RV; Boerger TF; Montpetit C; Kobaisi A; Lantz JM; Kumar V; Plener J; Demetriades AK; Wood L; Dastagir O; Treanor C; Toumbas G; Ammendolia C; Wilson N; Anderson DB;

Article GUID: 42253823

Author(s): Ellenbogen MA; Serravalle L; Hodgins S; Walker CD; Walker EF;

The offspring of parents with bipolar disorder (OBD) are at high risk for developing affective disorders. Low levels of organization and consistency in the home (parenting structure) is associated with increased behavioral problems and hypothalamic-pituitary-adrenal (HPA) reactivity in the OBD and thus may be an important developmental risk factor. We als ...

Article GUID: 42247738

Author(s): Paul J; Jäger ATP; Huck J; Tardif CL; Villringer A; Gauthier CJ; Bazin PL; Steele CJ;

Ultra-high field magnetic resonance imaging at sub-millimeter resolution opens the possibility to assess subtle longitudinal changes in brain structure and function. Identifying the regions and putative mechanisms involved in learning specific motor sequences is a key step towards understanding neuroplasticity. To disambiguate sequence-specific learning f ...

Article GUID: 42237744

Author(s): Abdallah W; Darwish A; Garcia J; Kadem L;

Background: Aortic regurgitation (AR) alters normal blood flow patterns in the left ventricle (LV), affecting diastolic filling dynamics, and is commonly quantified by the regurgitant fraction (RF). However, conventional diagnostic methods have notable limitations, prompting growing interest in four-dimensional flow magnetic resonance imaging (4D-flow MRI ...

Article GUID: 42228301

Author(s): Brancheriau CR; Larocque K; Schick G; Tountas I; Perlman A; Piekny A;

Cytokinesis, the final step of cell division, relies on ingression of a precisely positioned actomyosin ring. Chromatin-associated Ran-GTP fine-tunes ring position, although the mechanism remains unclear. We hypothesize that depletion of Ran-GTP between segregating chromosomes leads to equatorial enrichment of importins, promoting recruitment of the scaff ...

Article GUID: 42225064

Author(s): Calvano A; Xiao Y; Steidel K; Loehrer PA; Ruppert-Junck MC; Nimsky C; Timmermann L; Bopp MHA; Pedrosa DJ;

Purpose: Accurate segmentation of the subthalamic nucleus (STN) is paramount for optimising outcomes under deep brain stimulation (DBS) in Parkinson's disease (PD). Clinically available tools like Brainlab Elements (BL-E) enable automated segmentations for surgical planning, yet their spatial ...

Article GUID: 42225900

Author(s): Wang M; Bhagwat N; Cremonesi F; Dugré M; Pfarr JK; d' Angremont E; Dai A; Jahanpour A; Urchs S; Cansiz S; Chambon L; Dinçer AT; Torres J; Vesin M; Pinilla-Monsalve G; Song Y; Vriend C; Jeanson F; Monchi O; van der Werf YD; Lorenzi M ...

Despite growing understanding of the benefits of having Findable, Accessible, Interoperable, and Reusable (FAIR) data, many datasets still cannot be shared. Federated analysis methods can enable multisite studies that do not require the sharing of participant-level information. However, there are ...

Article GUID: 42146517

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional bra ...

Article GUID: 42208339