Author(s): Ozturk TN; Culham DE; Tempelhagen L; Wood JM; Lamoureux G;

Osmosensing transporter ProP detects the increase in cytoplasmic cation concentration associated with osmotically induced cell dehydration and mediates osmolyte uptake into bacteria. ProP is a 12-transmembrane helix protein with an a-helical, cytoplasmic C-terminal domain (CTD) linked to transmembrane helix XII (TM XII). It has been proposed that the CTD ...

Article GUID: 32838524

Author(s): Krohn L; Öztürk TN; Vanderperre B; Ouled Amar Bencheikh B; Ruskey JA; Laurent SB; Spiegelman D; Postuma RB; Arnulf I; Hu MTM; Dauvilliers Y; Högl B; Stefani A; Monaca CC; Plazzi G; Antelmi E; Ferini-Strambi L; Heidbreder A; Rudakou U; Co ...

Objective: The TMEM175/GAK/DGKQ locus is the 3rd strongest risk locus in genome-wide association studies of Parkinson disease (PD). We aimed to identify the specific disease-associated variants in this locus, and their potential implications. Methods: Full sequencing of TMEM175/GAK/DGKQ followed ...

Article GUID: 31658403

Author(s): Culham DE; Marom D; Boutin R; Garner J; Ozturk TN; Sahtout N; Tempelhagen L; Lamoureux G; Wood JM;

ProP is a member of the major facilitator superfamily, a proton-osmolyte symporter, and an osmosensing transporter. ProP proteins share extended cytoplasmic carboxyl terminal domains (CTDs) implicated in osmosensing. The CTDs of the best characterized, group A ProP orthologs, terminate in sequenc ...

Article GUID: 30448037