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Deformable detection transformers for domain adaptable ultrasound localization microscopy with robustness to point spread function variations

Author(s): Gharamaleki SK; Helfield B; Rivaz H;

Super-resolution imaging has emerged as a rapidly advancing field in diagnostic ultrasound. Ultrasound Localization Microscopy (ULM) achieves sub-wavelength precision in microvasculature imaging by tracking gas microbubbles (MBs) flowing through blood vessels. However, MB localization faces challenges due to dynamic point spread functions (PSFs) caused by ...

Article GUID: 40640235


Development of dual acid-visible light-degradable core-crosslinked nanogels with extended conjugate aromatic imines for enhanced drug delivery

Author(s): Bairagi K; Shamekhi M; Tountas I; Letourneau N; Peslherbe GH; Piekny A; Oh JK;

The development of stimuli-responsive amphiphilic block copolymers and their nanoassemblies/nanogels integrated with degradable covalent chemistry undergoing chemical transitions has been extensively explored as a promising platform for tumor-targeting controlled/enhanced drug delivery. The conjugate aromatic imine bond is unique in responding to acidic p ...

Article GUID: 40637173


Scapegoated communities, shared struggles: A call for solidarity with people who use drugs and queer and trans people

Author(s): London-Nadeau K; Barborini C; Haines-Saah R; Bazarov M; Bristowe S; Khorkhordina M; Lemay-Gaulin M; Gorka C; Juster RP; D' Alessio H; Chadi N;

Efforts to control, repress, and punish drug use and queer and trans existence are rising as right-wing extremism becomes increasingly mainstream. These connected efforts are seen through the stifling of bodily autonomy and agency using criminal-legal, biomedical and political apparatuses, and ha ...

Article GUID: 40633507


Inferring concussion history in athletes using pose and ground reaction force estimation and stability analysis of plyometric exercise videos

Author(s): Alves W; Babouras A; Martineau PA; Schutt D; Robbins S; Fevens T;

Concussions present a significant risk to athletes, with females exhibiting higher rates and prolonged recovery times than males. Current sideline concussion detection methods, such as the King-Devick test commonly used as a rapid screening tool designed to evaluate eye movement, attention, language, and cognitive processing abilities suffer from validity ...

Article GUID: 40632382


Sequencing of a Dairy Isolate Unlocks em Kluyveromyces marxianus /em as a Host for Lactose Valorization

Author(s): Thornbury M; Knoops A; Summerby-Murray I; Dhaliwal J; Johnson S; Utomo JC; Joshi J; Narcross L; Remondetto G; Pouliot M; Whiteway M; Martin VJJ;

The use of genetically modified nonconventional yeast provides significant potential for the bioeconomy by diversifying the tools available for the development of sustainable and novel products. In this study, we sequenced and annotated the genome of Kluyveromyces marxianus Y-1190 to establish it ...

Article GUID: 40629255


High-throughput screening and DFT characterization of bimetallic alloy catalysts for the nitrogen reduction reaction

Author(s): Shamekhi M; Toghraei A; Guay D; Peslherbe GH;

The lack of active and selective catalysts hinders transition to the electrochemical nitrogen reduction reaction (NRR) as an environmentally friendly route for on-site ammonia production under ambient conditions. In search of active NRR electrocatalysts, we generated a dataset of surface and ordered intermetallic alloys using density functional theory (DF ...

Article GUID: 40626812


Alzheimer model chip with microglia BV2 cells

Author(s): Yazdanpanah Moghadam E; Sonenberg N; Packirisamy M;

Amyloid beta oligomers (AßO) are pivotal in Alzheimer's Disease (AD), cleared by microglia cells, as immune cells in the brain. Microglia cells exposed to AßO are involved with migration, apoptosis, phagocytosis, and activated microglial receptors through AßO, impacting cellular mechanobiological characteristics such as microglial adhesion strength to ...

Article GUID: 40623989


Machine learning-assisted high-throughput prediction and experimental validation of high-responsivity extreme ultraviolet detectors

Author(s): Ayyubi RAW; Low MX; Salimi S; Khorsandi M; Hossain MM; Arooj H; Masood S; Zeb MH; Mahmood N; Bao Q; Walia S; Shabbir B;

Identifying materials with optimal optoelectronic properties for targeted applications represents both a critical need and a persistent challenge in optoelectronic device engineering. Machine learning models often depend on extensive datasets, which are typically lacking in specialized research d ...

Article GUID: 40624020


Sleep state influences early sound encoding at cortical but not subcortical levels

Author(s): Jourde HR; Coffey EBJ;

In sleep, the brain balances protecting processes like memory consolidation with preserving responsiveness to significant external stimuli. Although reductions in higher-level auditory processes during deeper sleep have been described, the sleep-dependent changes across levels of auditory hierarchy, particularly as regards early sound representations, rem ...

Article GUID: 40623839


Investigating the effects of a randomized, double-blinded aerobic, resistance, and cognitive training clinical trial on neurocognitive function in older adults with cardiovascular risk factors: the ACTIONcardioRisk protocol

Author(s): Bherer L; Vrinceanu T; Dupuy EG; Gayda M; Vincent T; Magnan PO; Mohammadi H; Gauthier C; Gagnon C; Duchesne S; Erickson KI; Gagnon D; Lesage F; Lupien S; Poirier J; Dubé MP; Thorin É; Juneau M; Breton J; Belleville S; Ferland G; Gaudreau ...

Background: Lifestyle factors like exercise and cognitive stimulation might help improve cognitive performance in older adults. However, studies investigating this, reported mixed results. Most of the data supporting the benefit of exercise comes from cross-sectional studies, cohort studies, or s ...

Article GUID: 40625372


Unraveling "Feeling Bad" in a Non-Western Culture: Achievement Emotions in Japanese Medical Students

Author(s): Nomura O; Sunohara M; Akatsu H; Wiseman J; Lajoie SP;

Introduction: The Medical Emotion Scale has been translated into Japanese (J-MES) and validated for cross-cultural emotion research in medical education. However, its applicability for extracting Japanese cultural aspects of medical students' emotions has not been examined. This study aimed to explore the underlying latent constructs related to cultur ...

Article GUID: 40625926


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