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Personalized biomarkers of multiscale functional alterations in temporal lobe epilepsy

Author(s): Xie K; Sahlas E; Ngo A; Chen J; Arafat T; Royer J; Zhou Y; Rodríguez-Cruces R; Dascal A; Caldairou B; Fadaie F; Barnett A; Audrain S; Larivière S; Caciagli L; Pana R; Weil AG; Grova C; Frauscher B; Schrader DV; Zhang Z; Concha L; Bernasc ...

Temporal lobe epilepsy (TLE) is the most common pharmacoresistant epilepsy in adults, yet few patients receive curative surgery due to diagnostic and prognostic uncertainty. In a multicenter cohort, we analyzed multimodal MRI and clinical data from 282 TLE patients, 298 healthy controls, and 45 d ...

Article GUID: 41258102


From pollution barriers to health buffers: Rethinking building airtightness under climate variability

Author(s): Fu N; Zhang R; Haghighat F; Kumar P; Cao SJ;

Climate change is reshaping indoor-outdoor pollution dynamics, yet current building standards rarely reflect this shift. In rapidly urbanizing regions with high ambient PM2.5 levels, building airtightness offers an underutilized strategy to mitigate indoor exposure and associated health burdens. An analysis of 36 major Chinese cities across five climate z ...

Article GUID: 41252997


Methotrexate plus low-dose prednisolone compared with high-dose corticosteroid therapy in the management of idiopathic granulomatous mastitis

Author(s): Shojaee L; Nafissi N; Roodposhti FN; Shakeriastani K; Shakeriastani K;

Purpose: Idiopathic granulomatous mastitis (IGM) is a chronic, relapsing inflammatory breast disease of unknown etiology. Its unpredictable course and unclear pathogenesis have made treatment a persistent clinical challenge. This study aimed to evaluate treatment outcomes in patients with IGM, focusing on extending remission periods and reducing relapse r ...

Article GUID: 41251719


Parametric instability in discrete models of spatiotemporally modulated materials

Author(s): Wu J; Yousefzadeh B;

We investigate the phenomenon of parametric instability in discrete models of spatiotemporally modulated materials. These materials are celebrated in part because they exhibit nonreciprocal transmission characteristics. However, parametric instability may occur for strong modulations, or occasionally even at very small modulation amplitudes, and prevent t ...

Article GUID: 41250313


Imagining the beat: causal evidence for dorsal premotor cortex (dPMC) role in beat imagery via transcranial magnetic stimulation (TMS)

Author(s): Lazzari G; Ferreri L; Cattaneo L; Penhune V; Lega C;

The ability to internally generate and maintain a rhythmic pulse, i.e., beat imagery, is a fundamental aspect of musical cognition. While recent theories propose that premotor regions support internal temporal predictions during rhythm perception and imagery, direct causal evidence remains limited. In this study, we investigated the specific contributions ...

Article GUID: 41248776


Mechanistic insights of plant-microbe interactions for enhancing the growth and productivity of plants under salt stress conditions for agricultural sustainability

Author(s): Sharma B; Negi R; Jyothi SR; Gupta A; Jhamta S; Yadav N; Kaur N; Puri P; Thakur SS; Bagavathiappan S; Thakur N; Shreaz S; Madouh TA; Yadav AN;

According to estimates from United Nations environmental program, salinity affects about 20% of agricultural land and 50% of farmland worldwide. Plants react to salinity stress by undergoing distinctive physiochemical, morphological, and molecular adaptations. Nonetheless, a number of mitigating ...

Article GUID: 41245209


Assessment of chemical extracts of urban air for endocrine disruption using a serie of in vitro bioassays: a case study in Montreal, Canada

Author(s): Gillet AP; Dong H; Liu L; Akiki C; Zhang X; Tian L; Wania F; Wade MG; Apparicio P; Bayen S; Delbes G;

Recent data indicate that urban air harbors a complex mixture of industrial chemicals, pesticides, and combustion by-products, many of which may act as endocrine-disrupting chemicals (EDCs). By interfering with the endocrine system, EDCs can affect human health. Hence, there is an urgent need to ...

Article GUID: 41242228


Temporal and Sex-Related Differences in Knee Biomechanics Over the Course of the Varsity Athletic Season: Pre- and Postseason Knee Kinematics in Collegiate Varsity Athletes Using Kinect

Author(s): Joseph T; Babouras A; Zhao KY; Corban J; Martineau PA;

Background: Anterior cruciate ligament (ACL) tears can be a source of significant morbidity, with the potential for career-altering implications for athletes who sustain them. Specific knee biomechanics during a drop vertical jump have been shown to be associated with an increased risk for ACL injury in collegiate varsity athletes. Presently, the evolutio ...

Article GUID: 41230424


Characterization of ORF19.7608 (PPP1), a biofilm-induced gene of Candida albicans

Author(s): Iwuchukwu NC; Costa ACBPD; Law C; Kim MJ; Mitchell AP; Whiteway M;

The opportunistic human pathogen Candida albicans is an important cause of nosocomial infections, in large part because of its propensity to form biofilms on indwelling medical devices such as catheters. The formation of these biofilms is controlled by a complex transcriptional network and involves over a thousand genes, many of which are uncharacterized. ...

Article GUID: 41218072


The impact of a personalized oral health instruction form on oral health indices in institutionalized older adults: a randomized, controlled, single-blinded clinical trial

Author(s): Chebib N; Rotzinger S; Maccarone-Ruetsche N; Sioufi R; Mojon P; Müller F;

Background: This RCT aimed to test the impact of an educational intervention, supported by a Personalized Oral Health Instruction Form (POIF), on oral health indices in institutionalized older adults. Methods: Older adults aged 65 years and above living in a long-term care facility were recruited. Baseline oral health indices were recorded for all partic ...

Article GUID: 41214684


From water to sediment: A meta-analysis of microplastic distribution and the impact of dams in reservoir ecosystems

Author(s): Gao W; Zhang P; Wang H; Yang X; An C;

Microplastics (MPs) have become major contaminants in freshwater ecosystems. While numerous studies have characterized MPs in reservoirs, a comprehensive synthesis focusing on in-reservoir variations and dam-related influences is still lacking. This study investigates the spatial distribution of MPs in reservoir water and sediment based on data synthesize ...

Article GUID: 41215774


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