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Exploiting fluctuations in gene expression to detect causal interactions between genes

Author(s): Joly-Smith E; Talpur MM; Allard P; Papazotos F; Potvin-Trottier L; Hilfinger A;

Characterizing and manipulating cellular behavior requires a mechanistic understanding of the causal interactions between cellular components. We present an approach to detect causal interactions between genes without the need to perturb the physiological state of cells. This approach exploits naturally occurring cell-to-cell variability which is experime ...

Article GUID: 41401079


Distinguishing Between Healthy and Unhealthy Newborns Based on Acoustic Features and Deep Learning Neural Networks Tuned by Bayesian Optimization and Random Search Algorithm

Author(s): Lahmiri S; Tadj C; Gargour C;

Voice analysis and classification for biomedical diagnosis purpose is receiving a growing attention to assist physicians in the decision-making process in clinical milieu. In this study, we develop and test deep feedforward neural networks (DFFNN) to distinguish between healthy and unhealthy newborns. The DFFNN are trained with acoustic features measured ...

Article GUID: 41294952


The Bug-Network (BugNet): A Global Experimental Network Testing the Effects of Invertebrate Herbivores and Fungal Pathogens on Plant Communities and Ecosystem Function in Open Ecosystems

Author(s): Kempel A; Adamidis GC; Anadón JD; Atkinson J; Auge H; Avtzis D; Bachelot B; Bashirzadeh M; Bota JL; Classen A; Constantinou I; Crawley M; de Bellis T; Dostal P; Ebeling A; Eisenhauer N; Eldridge DJ; Encina G; Estrada C; Everingham S; Fan ...

Plants are consumed by a variety of organisms, including herbivores and pathogens, which significantly impact plant biomass, diversity, community composition, and ecosystem functioning. While the impacts of vertebrate herbivores are well established, the effects of consumer groups such as insect ...

Article GUID: 41080499


Exploring Deep Magnetoencephalography via Thalamo-Cortical Sleep Spindles

Author(s): Rattray GF; Jourde HR; Baillet S; Coffey EBJ;

Subcortical brain regions like the thalamus are integral to numerous sensory and cognitive functions. Magnetoencephalography (MEG) enables the study of widespread brain networks with high temporal resolution, but the degree to which deep sources like the thalamus can be resolved remains unclear. Functional connectivity methods may enhance differentiation, ...

Article GUID: 41002111


Cooperative Schemes for Joint Latency and Energy Consumption Minimization in UAV-MEC Networks

Author(s): Cheng M; He S; Pan Y; Lin M; Zhu WP;

The Internet of Things (IoT) has promoted emerging applications that require massive device collaboration, heavy computation, and stringent latency. Unmanned aerial vehicle (UAV)-assisted mobile edge computing (MEC) systems can provide flexible services for user devices (UDs) with wide coverage. The optimization of both latency and energy consumption rema ...

Article GUID: 40942666


Efficient neural encoding as revealed by bilingualism

Author(s): Moore C; Donhauser PW; Klein D; Byers-Heinlein K;

The remarkable human capacity for bilingual and multilingual acquisition raises fundamental questions about how the brain develops efficient systems for processing multiple languages. In this study, we used neural network models trained on natural speech input to examine how these efficient representations emerge. Our models show that multiple phonologica ...

Article GUID: 40828024


Personalizing brain stimulation: continual learning for sleep spindle detection

Author(s): Sobral M; Jourde HR; Marjani Bajestani SE; Coffey EBJ; Beltrame G;

Personalized closed-loop brain stimulation, in which algorithms used to detect neural events adapt to a user's unique neural characteristics, may be crucial to enable optimized and consistent stimulation quality for both fundamental research and clinical applications. Precise stimulation of sleep spindles-transient patterns of brain activity that occu ...

Article GUID: 40609549


PARPAL: PARalog Protein Redistribution using Abundance and Localization in Yeast Database

Author(s): Greco BM; Zapata G; Dandage R; Papkov M; Pereira V; Lefebvre F; Bourque G; Parts L; Kuzmin E;

Whole-genome duplication (WGD) events are common across various organisms; however, the retention and evolution of WGD paralogs is not fully understood. Quantitative measure of protein redistribution in response to the deletion of their WGD paralog provides insight into sources of gene retention. ...

Article GUID: 40580499


Hearing loss is associated with decreased default-mode network connectivity in individuals with mild cognitive impairment

Author(s): Grant N; Phillips N;

Mild cognitive impairment (MCI) and hearing loss (HL) have been separately associated with increased dementia risk. These highly co-occurring dementia risk factors are associated with aberrant functional brain connectivity. In individuals with HL aberrant functional connectivity has been associated with cognitive impairment. In individuals with MCI, aberr ...

Article GUID: 40567819


Distributed adaptive sliding mode control with deep recurrent neural network for cooperative robotic system in automated fiber placement

Author(s): Zhu N; Xie WF;

In this article, a distributed control strategy using an adaptive sliding mode controller (ASMC) is proposed for a 13-degree-of-freedom (13-DOF) cooperative robotic system in the field of automated fiber placement (AFP). A distributed control structure with event-triggered mechanism is developed to guarantee the desired cooperation performance and reduce ...

Article GUID: 40436653


CASCADE-FSL: Few-shot learning for collateral evaluation in ischemic stroke

Author(s): Aktar M; Tampieri D; Xiao Y; Rivaz H; Kersten-Oertel M;

Assessing collateral circulation is essential in determining the best treatment for ischemic stroke patients as good collaterals lead to different treatment options, i.e., thrombectomy, whereas poor collaterals can adversely affect the treatment by leading to excess bleeding and eventually death. To reduce inter- and intra-rater variability and save time ...

Article GUID: 40250214


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