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Beyond the Illusion of Controlled Environments: How to Embrace Ecological Pertinence in Research?

Author(s): Cassandre Vielle

Through the lens of preclinical research on substance use disorders (SUD), I propose a reflection aimed at re-evaluating animal models in neuroscience, with a focus on ecological relevance. While rodent models have provided valuable insights into the neurobiology of SUD, the field currently faces a validation crisis, with findings often failing to transla ...

Article GUID: 39777969


Psychosocial Function in Mild Cognitive Impairment: Social Participation is Associated With Cognitive Performance in Multiple Domains

Author(s): Rehan S; Phillips NA;

Psychosocial function is associated with cognitive performance cross-sectionally and cognitive decline over time. Using data from the COMPASS-ND study, we examined associations between psychosocial and cognitive function in 126 individuals with mild cognitive impairment, an at-risk group for Alzheimer's disease (AD). Psychosocial function was measured ...

Article GUID: 39773214


Semantically-Enhanced Feature Extraction with CLIP and Transformer Networks for Driver Fatigue Detection

Author(s): Gao Z; Chen X; Xu J; Yu R; Zhang H; Yang J;

Drowsy driving is a leading cause of commercial vehicle traffic crashes. The trend is to train fatigue detection models using deep neural networks on driver video data, but challenges remain in coarse and incomplete high-level feature extraction and network architecture optimization. This paper pioneers the use of the CLIP (Contrastive Language-Image Pre- ...

Article GUID: 39771685


Translating Evidence-Based Self-Management Interventions Using a Stepped-Care Approach for Patients With Cancer and Their Caregivers: A Pilot Sequential Multiple Assignment Randomized Trial Design

Author(s): Lambert S; Moodie EEM; McCusker J; Lokhorst M; Harris C; Langmuir T; Belzile E; Laizner AM; Brahim LO; Wasserman S; Chehayeb S; Vickers M; Duncan L; Esplen MJ; Maheu C; Howell D; de Raad M;

Background: Self-directed interventions are cost-effective for patients with cancer and their family caregivers, but barriers to use can compromise adherence and efficacy. Aim: Pilot a Sequential Multiple Assignment Randomized Trial (SMART) to develop a time-varying dyadic self-management interv ...

Article GUID: 39763142


Human Auditory-Motor Networks Show Frequency-Specific Phase-Based Coupling in Resting-State MEG

Author(s): Bedford O; Noly-Gandon A; Ara A; Wiesman AI; Albouy P; Baillet S; Penhune V; Zatorre RJ;

Perception and production of music and speech rely on auditory-motor coupling, a mechanism which has been linked to temporally precise oscillatory coupling between auditory and motor regions of the human brain, particularly in the beta frequency band. Recently, brain imaging studies using magnetoencephalography (MEG) have also shown that accurate auditory ...

Article GUID: 39757971


Evoked and entrained pupillary activity while moving to preferred tempo and beyond

Author(s): Spiech C; Hope M; Bégel V;

People synchronize their movements more easily to rhythms with tempi closer to their preferred motor rates than with faster or slower ones. More efficient coupling at one's preferred rate, compared to faster or slower rates, should be associated with lower cognitive demands and better attentional entrainment, as predicted by dynamical system theories ...

Article GUID: 39758823


Automated abdominal aortic calcification and major adverse cardiovascular events in people undergoing osteoporosis screening: the Manitoba Bone Mineral Density Registry

Author(s): Smith C; Sim M; Ilyas Z; Gilani SZ; Suter D; Reid S; Monchka BA; Jozani MJ; Figtree G; Schousboe JT; Lewis JR; Leslie WD;

Vertebral fracture assessment (VFA) images from bone density machines enable the automated machine learning assessment of abdominal aortic calcification (ML-AAC), a marker of cardiovascular disease (CVD) risk. The objective of this study was to describe the risk of a major adverse cardiovascular ...

Article GUID: 39749990


PreVISE: an efficient virtual reality system for SEEG surgical planning

Author(s): Spiegler P; Abdelsalam H; Hellum O; Hadjinicolaou A; Weil AG; Xiao Y;

Epilepsy is a neurological disorder characterized by recurring seizures that can cause a wide range of symptoms. Stereo-electroencephalography (SEEG) is a diagnostic procedure where multiple electrodes are stereotactically implanted within predefined brain regions to identify the seizure onset zone, which needs to be surgically removed or disconnected to ...

Article GUID: 39735694


Progesterone and allopregnanolone facilitate excitatory synaptic transmission in the infralimbic cortex via activation of membrane progesterone receptors

Author(s): Rahaei N; Buynack LM; Kires L; Movasseghi Y; Chapman CA;

Estrogens and progesterone can have rapid effects on neuronal function and can modify the use of spatial navigation strategies dependent upon the prefrontal cortex, striatum, and hippocampus. Here, we assessed the effects of 17ß-estradiol (E2), progesterone, and its metabolite allopregnanolone, on evoked excitatory postsynaptic potentials in the infralimb ...

Article GUID: 39722289


Butyl Acrylate/2-Methylene-1,3-Dioxepane/Vinyl Acetate Emulsion Terpolymerization: Incorporating Backbone Degradable Linkages into Adhesive Applications

Author(s): Meek K; Movafagh M; Dubé MA;

The ring-opening polymerization of bio-based monomer 2-methylene-1,3-dioxepane (MDO) can reportedly enhance polymer degradability. Butyl acrylate (BA)/MDO/vinyl acetate (VAc) terpolymers were synthesized via emulsion polymerization for their eventual application as pressure-sensitive adhesives (PSAs). While using MDO in emulsion polymerization leads to a ...

Article GUID: 39719378


Insights from multiple stable isotopes (C, N, Cl) into the photodegradation of herbicides atrazine and metolachlor

Author(s): Levesque-Vargas M; Ohlund L; Sleno L; Gélinas Y; Höhener P; Ponsin V;

Many processes can contribute to the attenuation of the frequently detected and toxic herbicides atrazine and metolachlor in surface water, including photodegradation. Multi-element compound-specific isotope analysis has the potential to decipher between these different degradation pathways as Cl is a promising tool for both pathway identification and a s ...

Article GUID: 39716600


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