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BOLD Long-Range Temporal Correlations Reflect Changes in Language and Depression Across Intensive Aphasia Therapy

Author(s): Jäger AP; Steele CJ; Dreyer FR; Osterloh MR; Sadlon A; Nikulin V; Mohr B; Pulvermüller F;

Background: Intensive language-action therapy treats language deficits and depressive symptoms in chronic poststroke aphasia, yet the underlying neural mechanisms remain underexplored. Long-range temporal correlations (LRTCs) in blood oxygenation level-dependent signals indicate persistence in brain activity patterns and may relate to learning and levels ...

Article GUID: 40927858


Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk

Author(s): Crane AL; Feyten LEA; Brusseau AJP; Dumaresq Synnott F; Ramnarine IW; Ferrari MCO; Brown GE;

The fear of predation is pervasive among vertebrate prey species, being characterized by neurobiological and behavioral changes induced by risk exposure. To understand the acquisition and attenuation of fearful phenotypes, such as dimensions of posttraumatic stress, researchers often use animal m ...

Article GUID: 40905336


Anxiolytic effects of diazepam in Trinidadian guppies exposed to chemical cues indicating predation risk

Author(s): Crane AL; Feyten LEA; Brusseau AJP; Dumaresq Synnott F; Ramnarine IW; Ferrari MCO; Brown GE;

The fear of predation is pervasive among vertebrate prey species, being characterized by neurobiological and behavioral changes induced by risk exposure. To understand the acquisition and attenuation of fearful phenotypes, such as dimensions of posttraumatic stress, researchers often use animal m ...

Article GUID: 40905351


Aerobic fitness modulates arithmetic strategy use in college-aged young adults

Author(s): McGowan AL; Ellison OK; Ham MS; Chandler MC; Pontifex MB;

Purpose: The purpose of the present investigation was to determine the extent to which individuals at the extremes of the aerobic fitness continuum differed in their utilization of arithmetic strategies. Method: Using a cross-sectional design, 37 higher aerobically fit and 37 lower aerobically fit participants completed a complex arithmetic task while ne ...

Article GUID: 40889823


A novel span and syntax enhanced large language model based framework for fine-grained sentiment analysis

Author(s): Zou H; Wang Y; Huang A;

Fine-grained aspect-based sentiment analysis requires language models to identify aspect entities and the corresponding sentiment information in the input text content. Transformer-based pre-trained large language models have demonstrated remarkable performance on various challenging natural language processing tasks. However, large language models face l ...

Article GUID: 40876298


Development and Application of Children s Sex- and Age-Specific Fat-Mass and Muscle-Mass Reference Curves From Dual-Energy X-Ray Absorptiometry Data for Predicting Cardiometabolic Risk

Author(s): Saputra ST; Van Hulst A; Henderson M; Brugiapaglia S; Faustini C; Kakinami L;

Background: A dual-energy x-ray absorptiometry (DXA)-derived phenotype classification based on fat mass and muscle mass has been developed for adults. We extended this to a paediatric population. Methods: Children's (= 17 years) DXA data in NHANES (n = 6120) were used to generate sex- and age-specific deciles of appendicular skeletal muscle mass inde ...

Article GUID: 40878792


ASSOBRAFIR clinical practice guidelines in cardiovascular physical therapy: Exercise-based interventions in outpatient rehabilitation programs for heart failure

Author(s): Karsten M; Gardenghi G; Arruda ACT; Catai AM; Vieira AM; Stein C; de Araujo CLP; Pereira DAG; Matte DL; da Silva FMF; Guimarães FS; Ghisi GLM; Chiappa GRS; Sbruzzi G; Cipriano GFB; Ribeiro GDS; Milani JGPO; Neves LMT; Calegari L; Morais ...

Background: Exercise training is a core component of cardiovascular rehabilitation programs for patients with heart failure (HF). In Brazil, physical therapists frequently deliver rehabilitation interventions. Given heart failure clinical management advancements and varied rehabilitation approach ...

Article GUID: 40857977


Obsessive-compulsive symptoms moderate the effect of contamination motion on disgust intensity

Author(s): Pelzer M; Ouellet-Courtois C; Krause S; Coughtrey A; Fink-Lamotte J;

Background: Perceiving a threat as constantly evolving, coming closer and escalating quickly can result in looming vulnerability (LV). LV may be a distal factor in contamination-based OCD (C-OCD) influencing disorder-specific mechanisms such as disgust. The aim of this study was to gain knowledge about three components of LV: speed, proximity and accelera ...

Article GUID: 40858003


An examination of the quinic acid utilization genes in Aspergillus niger reveals the involvement of two pH-dependent permeases

Author(s): Sgro M; Reid ID; Arentshorst M; Ram AFJ; Tsang A;

Many microorganisms are able to use plant-derived aromatic and cyclic compounds like the common plant secondary metabolite quinic acid as carbon and energy sources. In fungi, three enzymatic steps convert quinic acid into the common intermediate protocatechuic acid, which is then further converted into TCA cycle intermediates. The genes encoding these thr ...

Article GUID: 40853219


Deep learning-based feature discovery for decoding phenotypic plasticity in pediatric high-grade gliomas single-cell transcriptomics

Author(s): Abicumaran Uthamacumaran

Advancements in AI-powered systems medicine have revolutionized biomarker discovery through emergent and explainable features. By use of complex network dynamics and graph-based machine learning, we identified critical determinants of lineage-specific plasticity across the single-cell transcriptomics of pediatric high-grade glioma (pHGGs) subtypes: IDHWT ...

Article GUID: 40848317


The age of obesity onset affects changes in subcutaneous adipose tissue macrophages and T cells after weight loss

Author(s): Murphy J; Morais JA; Tsoukas MA; Cooke AB; Daskalopoulou SS; Santosa S;

Introduction: Adipose tissue inflammation, driven in part by immune cells, may contribute to the elevated type 2 diabetes risk in adults with childhood-onset obesity (CO) compared to those with adult-onset obesity (AO). Weight loss can modify adipose tissue immune cell composition, but whether these changes differ by obesity onset remains unknown. Method ...

Article GUID: 40831565


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