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Microglial senescence in neurodegeneration: Insights, implications, and therapeutic opportunities

Author(s): Samuel Olajide T; Oyerinde TO; Omotosho OI; Okeowo OM; Olajide OJ; Ijomone OM;

The existing literature on neurodegenerative diseases (NDDs) reveals a common pathological feature: the accumulation of misfolded proteins. However, the heterogeneity in disease onset mechanisms and the specific brain regions affected complicates the unders ...

Article GUID: 39364217


Hypothalamic-pituitary-adrenal axis function in the offspring of parents with bipolar disorder and the impact of the family environment: A pilot study of the Reducing Unwanted Stress in the Home (RUSH) prevention program

Author(s): Ping EY; Herriot H; Iacono V; Serravalle L; Ellenbogen MA;

Background: The home environment of offspring of parents with bipolar disorder (OBD) has been characterized by high levels of stress and disorganization, which may impact development of the hypothalamic-pituitary-adrenal (HPA) axis and their subsequent risk ...

Article GUID: 39357242


How to evaluate local fit (residuals) in large structural equation models

Author(s): Rex B Kline

Consistent with reporting standards for structural equation modelling (SEM), model fit should be evaluated at two different levels, global and local. Global fit concerns the overall or average correspondence between the entire data matrix and the model, giv ...

Article GUID: 39359027


The temporal sequence and reciprocal relationships of frailty, social isolation and loneliness in older adults across 21 years

Author(s): Mehrabi F; Pomeroy ML; Cudjoe TKM; Jenkins E; Dent E; Hoogendijk EO;

Background: It is unclear whether social isolation and loneliness may precede frailty status or whether frailty may precipitate social isolation and loneliness. We investigated the reciprocal and temporal sequence of social isolation, loneliness, and frailt ...

Article GUID: 39360435


Reduction of Cr(VI) by Bacillus toyonensis LBA36 and its effect on radish seedlings under Cr(VI) stress

Author(s): Tan A; Wang H; Zhang H; Zhang L; Yao H; Chen Z;

Chromium, being among the most toxic heavy metals, continues to demand immediate attention in the remediation of Cr-contaminated environments. In this study, a strain of LBA36 (Bacillus toyonensis) was isolated from heavy metal contaminated soil in Luanchua ...

Article GUID: 39346031


Leveraging Personal Technologies in the Treatment of Schizophrenia Spectrum Disorders: Scoping Review

Author(s): D' Arcey J; Torous J; Asuncion TR; Tackaberry-Giddens L; Zahid A; Ishak M; Foussias G; Kidd S; ...

Background: Digital mental health is a rapidly growing field with an increasing evidence base due to its potential scalability and impacts on access to mental health care. Further, within underfund ...

Article GUID: 39348196


Comprehensive Analysis of Age- and Sex-Related Expression of the Chaperone Protein Sigma-1R in the Mouse Brain

Author(s): Tarmoun K; Lachance V; Le Corvec V; BĂ©langer SM; Beaucaire G; Kourrich S;

Sigma-1R (S1R) is a ubiquitously distributed protein highly expressed in the brain and liver. It acts as a ligand-inducible chaperone protein localized at the endoplasmic reticulum. S1R participates in several signaling pathways that oversee diverse cellula ...

Article GUID: 39335377


"We don't do any of these things because we are a death-denying culture": Sociocultural perspectives of Black and Latinx cancer caregivers

Author(s): Nwakasi C; Esiaka D; Nweke C; Chidebe RCW; Villamar W; de Medeiros K;

Objectives: Cancer is an enormous public health burden among Black and Latinx cancer survivors, and they are at risk of facing barriers to accessing cancer treatment and support in the United States. This study explored the unique challenges and experiences ...

Article GUID: 39327878


Fe/GMP functional nanomaterial enhancing the denitrification efficiency by bi-signal regulation: Electron transfer and microbial community

Author(s): Hao Y; Guo T; Li H; Liu W; Chen Z; Zhang W; Wang X; Guo J;

A novel functional nanomaterial composed of guanosine monophosphate (GMP) and Fe enhanced denitrification efficiency by regulating electron transfer and microbial community. Fe/GMP enhanced nitrate (NO3-) degradation rates by 3.00-fold in serum vial batch e ...

Article GUID: 39326537


Family shapes child development: The role of codevelopmental trajectories of interparental conflict and emotional warmth for children's longitudinal development of internalizing and externalizing problems

Author(s): Zemp M; Fang S; Johnson MD;

This study aimed (1) to identify distinct family trajectory profiles of destructive interparental conflict and parent-child emotional warmth reported by one parent, and (2) to examine whether these codevelopmental profiles were associated with the longitudi ...

Article GUID: 39323207


Neuroinflammation and oxidative redox imbalance drive memory dysfunction in adolescent rats prenatally exposed to Datura Stramonium

Author(s): Bamisi O; Oluwalabani AO; Arogundade TT; Olajide OJ;

Although there have been reports indicating that Datura Stramonium (D. stramonium) may induce anticholinergic and neuropsychiatry effects, the compound is still being used for recreational and medicinal purposes while ingestion during pregnancy has been doc ...

Article GUID: 39303770


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