Author(s): Yan B; Huang F; Ying J; Zhou D; Norouzi S; Zhang X; Wang B; Liu F;

Antibiotics are increasingly prevalent in global environments, driving antimicrobial resistance and disrupting microbial cycling. These impacts pose threats to human, animal, and environmental health. Therefore, addressing this emergent issue necessitates a One Health framework that integrates these interconnected dimensions. Here we systematically review ...

Article GUID: 40469481

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519

Author(s): Bin X; Pawelek PD;

The Escherichia coli enterobactin biosynthetic protein EntB is a bifunctional enzyme that catalyzes hydrolysis of isochorismate via its N-terminal isochorismatase (IC) domain, and then transfers phosphopantetheinylated 2,3-DHB to EntF via the EntB C-terminal aryl carrier protein (ArCP) domain. Here we used a fluorescence anisotropy binding assay to invest ...

Article GUID: 40400396

Author(s): Pinto SM; Cheung JPY; Samartzis D; Karppinen J; Zheng YP; Pang MYC; Fortin M; Wong AYL;

Background: Although individuals with chronic low back pain (CLBP) show increased fatty infiltration in the lumbar multifidus muscle (LMM), it remains unclear whether LMM changes are related to clinical outcomes (such as pain and disability) after considering confounders (spinal phenotypes, fear-avoidance beliefs [FABs] and insomnia). This study examined: ...

Article GUID: 40376565

Author(s): Wu KY; Dave A; Nirwal GK; Giunta M; Nguyen VDH; Tran SD;

Exosomes, a subset of extracellular vesicles, have emerged as potential therapeutic agents in ophthalmology due to their ability to modulate immune responses, facilitate cellular communication, and promote tissue repair. This chapter explores the potential applications of exosome-based therapies in corneal and anterior segment disorders, retinal diseases, ...

Article GUID: 40360847

Author(s): Bögershausen N; Cavdarli B; Nagai T; Milev MP; Wolff A; Mehranfar M; Schmidt J; Choudhary D; Gutiérrez-Gutiérrez Ó; Cyganek L; Saint-Dic D; Zibat A; Köhrer K; Wollenweber TE; Wieczorek D; Altmüller J; Borodina T; Kaçar D; Haliloglu G; Li ...

As a major component of intracellular trafficking, the coat protein complex II (COPII) is indispensable for cellular function during embryonic development and throughout life. The four SEC24 proteins (A-D) are essential COPII components involved in cargo selection and packaging. A human disorder ...

Article GUID: 40131364

Author(s): Sun Y; Bakhtiari S; Valente-Paterno M; Jiang H; Zerges W;

A small genome in chloroplasts encodes many of the polypeptide subunits of the photosynthetic electron transport complexes embedded in the membranes of thylakoid vesicles in the chloroplast stroma and synthesized by ribosomes of the bacterial-like genetic system of this semiautonomous organelle. While thylakoid membranes are sites of translation, evidence ...

Article GUID: 40116843

Author(s): Bouchard R; Babin C; Normandeau E; Xuereb A; Boulanger F; Coxon A; Diamond S; Fireman R; Lameboy J; Louttit N; Natawapineskum G; Okimaw D; Torio D; Varty S; Moore JS; Fraser D; Bernatchez L;

Dispersal is a highly variable trait influenced by life history and ecological factors, affecting gene flow when dispersers successfully reproduce. Anadromous salmonids, with their diverse migratory strategies and ecological traits, serve as an ideal model for studying dispersal evolution, showca ...

Article GUID: 40108992

Author(s): Lapointe VA; Dubé S; Rukhlyadyev S; Kessai T; Lafortune D;

Fueled by advances in artificial intelligence (AI), the adult entertainment industry is undergoing a significant transformation. AI-generated pornography-or AI porn-is reshaping how people create and consume sexually explicit content, progressively offering rapid, mass access to large quantities of interactive and highly customizable experiences. Yet, des ...

Article GUID: 40032709

Author(s): Pacheco-Gomez BL; Zepeda-Ruiz WA; Velazquez-Lopez D; Shizgal P; Velazquez-Martinez DN;

Rewarding electrical brain stimulation (EBS) can serve as a discriminative stimulus. It has long been suspected that this discriminative property reflects the subjective intensity of the rewarding effect. In turn, the counter model of spatiotemporal integration attributes the subjective reward intensity produced by a stimulation train of fixed duration to ...

Article GUID: 40015584

Author(s): Gibelli J; Won H; Michaelides S; Jeon HB; Fraser DJ;

The contributions of distinct populations to annual harvests provide key insights to conservation, especially in migratory species that return to specific reproductive areas. In this context, genetic stock identification (GSI) requires reference samples from source populations to assign harvested individuals, yet sampling might be challenging as reproduct ...

Article GUID: 39995301