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Low levels of organization and consistency in the home in middle childhood predicts cortisol levels and internalizing symptoms 12 years later among the offspring of parents with bipolar disorder

Author(s): Ellenbogen MA; Serravalle L; Hodgins S; Walker CD; Walker EF;

The offspring of parents with bipolar disorder (OBD) are at high risk for developing affective disorders. Low levels of organization and consistency in the home (parenting structure) is associated with increased behavioral problems and hypothalamic-pituitary-adrenal (HPA) reactivity in the OBD and thus may be an important developmental risk factor. We a ...

Article GUID: 42247738


Multilingualism and cognitive reserve in older adults with, or at risk for, Alzheimer s disease: Evidence from resting-state functional connectivity

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional b ...

Article GUID: 42208339


Investigating substrate specificity in arogenate versus prephenate dehydratases

Author(s): Clayton EJ; Smith-Uffen M; Tribble TW; Duennwald ML; Kohalmi SE;

Background: Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, re ...

Article GUID: 42204708


The effect of a multimodal exercise program on paraspinal muscle morphology and clinical outcomes in chronic low back pain

Author(s): Rosenstein B; Bergevin M; Bobeuf F; Bherer L; Pageaux B; Roy M; Fortin M;

Background: Multimodal exercise programs do not specifically target lumbar paraspinal musculature, but incorporate aspects of different exercises to have an overall benefit. Objective: To investigate the effect of a multimodal exercise program on paraspinal muscle volume and composition, and patient outcomes in individuals with chronic low back pain (C ...

Article GUID: 42093855


A Functional Shape Framework for the Detection of Multiple Sclerosis Using Optical Coherence Tomography Images

Author(s): Tahvilian H; Kafieh R; Ashtari F; Swamy MNS; Ahmad MO;

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease. Optical coherence tomography (OCT) is a non-invasive imaging technique of the retina. The thickness of the ganglion cell-inner plexiform layer (GCIPL) obtained from an OCT image is a valuable biomarker for monitoring MS. Since the functional shape (F-shape)-based technique has pro ...

Article GUID: 42076512


Effects of aquatic therapy vs. standard care on gluteal muscle morphology and function in individuals with chronic low back pain: a randomized controlled trial

Author(s): Montpetit C; Vaillancourt N; Rosenstein B; Wesselink EO; Dover G; Weiss C; Papula LA; Melek A; Weber KA; Elliott JM; Fortin M;

Article GUID: 41943153


Probing cognitive reserve with resting state functional connectivity in subcortical ischemic vascular cognitive impairment

Author(s): Gu Y; Hsu CL; Boa Sorte Silva NC; Tam RC; Alkeridy WA; Lam K; Liu-Ambrose T;

Background: Subcortical ischemic vascular cognitive impairment (SIVCI) is characterized by white matter hyperintensities (WMH) that contribute to executive dysfunction and increased risk of Alzheimer's disease. Cognitive reserve (CR) is the brain's ability to maintain cognitive performance despite pathology. Resting-state functional connectivity ...

Article GUID: 41929984


On traits matching and the modular organization of food web and occurrence networks

Author(s): Borzone Mas D; Scarabotti PA; Vaschetto PA; Alvarenga P; Vazquez M; Arim M;

Modularity and nestedness have been observed recurrently across different ecological networks, including food webs and occurrence networks. These patterns emerge from species-level processes, where interactions and occurrences are determined by niche-based and/or abundance-based mechanisms. Abundance-based processes promote nested networks with gradient ...

Article GUID: 41840807


The Functionality Appreciation Scale: An examination of its psychometric properties in a French-Canadian adult sample

Author(s): Maïano C; Swami V; Tylka TL; Aimé A;

The 7-item Functionality Appreciation Scale (FAS) is a widely used instrument to assess functionality appreciation, a central facet of positive body image. Here, we examined the psychometric properties of a novel French translation of the FAS. French-speaking Canadian adults were asked to complete the FAS and validated measures of positive body image, p ...

Article GUID: 41687325


Measurement invariance and differential item functioning of the Functionality Appreciation Scale (FAS) in five latin american nations

Author(s): Mebarak M; Maïano C; Mendoza J; Chirullo V; Coneo AMC; Compte EJ; Cruz-Licea V; Góngora VC; Henríquez C; Martínez-Banfi M; Mejía Rodriguez DL; Pescetto I; Selma H; Boothroyd LG; Thornborrow T; Todd J; Swami V;

The Functionality Appreciation Scale (FAS) is increasingly used within diverse national and linguistic contexts, but assessments of its functioning across groups remains limited. To extend knowledge, we examined measurement invariance of the FAS across five Latin American nations (Argentina, Ch ...

Article GUID: 41547175


Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults

Author(s): Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved bra ...

Article GUID: 41543005


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