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Global antibiotic hotspots and risks: A One Health assessment

Author(s): Yan B; Huang F; Ying J; Zhou D; Norouzi S; Zhang X; Wang B; Liu F;

Antibiotics are increasingly prevalent in global environments, driving antimicrobial resistance and disrupting microbial cycling. These impacts pose threats to human, animal, and environmental health. Therefore, addressing this emergent issue necessitates a One Health framework that integrates these interconnected dimensions. Here we systematically review ...

Article GUID: 40469481


Adaptive finite-time synchronized control of multi-robotic fiber placement system with model uncertainties and disturbances

Author(s): Zhang R; Wang Y; Xie W; Li P; Tan H; Jiang Y;

The use of multiple robots to manufacture composite components represents a critical development direction for fiber placement systems (FPSs). In multi-robotic fiber placement systems (MRFPSs) with heterogeneous mechanical structures, robots collaborate to perform fiber placement tasks. Consequently, robot synchronization emerges as a primary factor in de ...

Article GUID: 40461302


Functions of Informal Subgroups in Relation to Work Groups and Group Effectiveness

Author(s): Sidorenkov AV; Borokhovski EF;

Article GUID: 40459704


Trilingual families language strategies: potential predictors and effect on trilingual exposure

Author(s): Quirk E; Hadeed N; Byers-Heinlein K;

Family language strategies are approaches that parents adopt for language use with their multilingual children. In bilingual contexts, these strategies influence children's language exposure and development (Macleod et al., 2022). In the more complex context of trilingualism, how families settle on strategies and their relationship with exposure may d ...

Article GUID: 40443954


Repurposing Sigma-1 Receptor-Targeting Drugs for Therapeutic Advances in Neurodegenerative Disorders

Author(s): Eskandari K; Bélanger SM; Lachance V; Kourrich S;

Neurodegenerative disorders, such as Alzheimer's, Parkinson's, and Huntington's disease, due to their multifaced and complicated nature, remain uncurable and impose substantial financial and human burdens on society. Therefore, developing new innovative therapeutic strategies is vital. In this context, drug repurposing has emerged as a promisi ...

Article GUID: 40430519


Modulatory effects of M3 muscarinic acetylcholine receptor on inflammatory profiles of human memory T helper cells

Author(s): Gholizadeh F; Hajiaghayi M; Choi JS; Little SR; Rahbari N; Kargar M; Brotto K; Han E; Shih SCC; Darlington PJ;

Memory T helper (Th) cells, generated in response to immunogenic challenges, are crucial in orchestrating adaptive immune responses. Acetylcholine (ACh), a key neurotransmitter of the parasympathetic nervous system, modulates immune function via muscarinic ACh receptors (mAChRs). This study inves ...

Article GUID: 40405417


The enterobactin biosynthetic intermediate 2,3-dihydroxybenzoic acid is a competitive inhibitor of the Escherichia coli isochorismatase EntB

Author(s): Bin X; Pawelek PD;

The Escherichia coli enterobactin biosynthetic protein EntB is a bifunctional enzyme that catalyzes hydrolysis of isochorismate via its N-terminal isochorismatase (IC) domain, and then transfers phosphopantetheinylated 2,3-DHB to EntF via the EntB C-terminal aryl carrier protein (ArCP) domain. Here we used a fluorescence anisotropy binding assay to invest ...

Article GUID: 40400396


Development and validation of the multidimensional Fear of Depression Recurrence Questionnaire (FoDRQ)

Author(s): Gumuchian ST; Boyle A; Kennedy G; Wong SF; Ellenbogen MA;

Despite high recurrence rates in major depressive disorder (MDD), little is known about the factors influencing recurrence. Understanding the changes that occur between major depressive episodes (MDEs) is imperative. It is possible that being fearful of experiencing another MDE may lead to cognitive and behavioural changes that increase MDD recurrence ris ...

Article GUID: 40391691


Relationship Between Lumbar Multifidus Morphometry and Pain/Disability in Individuals With Chronic Nonspecific Low Back Pain After Considering Demographics, Fear-Avoidance Beliefs, Insomnia, and Spinal Degenerative Changes

Author(s): Pinto SM; Cheung JPY; Samartzis D; Karppinen J; Zheng YP; Pang MYC; Fortin M; Wong AYL;

Background: Although individuals with chronic low back pain (CLBP) show increased fatty infiltration in the lumbar multifidus muscle (LMM), it remains unclear whether LMM changes are related to clinical outcomes (such as pain and disability) after considering confounders (spinal phenotypes, fear-avoidance beliefs [FABs] and insomnia). This study examined: ...

Article GUID: 40376565


Exosome Innovations in Ophthalmology and Sjögren s Syndrome

Author(s): Wu KY; Dave A; Nirwal GK; Giunta M; Nguyen VDH; Tran SD;

Exosomes, a subset of extracellular vesicles, have emerged as potential therapeutic agents in ophthalmology due to their ability to modulate immune responses, facilitate cellular communication, and promote tissue repair. This chapter explores the potential applications of exosome-based therapies in corneal and anterior segment disorders, retinal diseases, ...

Article GUID: 40360847


Biopsychosocial risk factors for pain in early phases of pediatric cancer treatment

Author(s): Klages KL; James RN; Kain ZN; Phipps S; Alberts NM; Fortier MA;

Introduction: Cancer pain remains a significant burden among children with cancer, and many patients experience pain starting around the time of diagnosis and throughout the course of treatment. A biopsychosocial treatment approach has been recommended to improve pain management in this population; however, specific psychosocial factors that contribute to ...

Article GUID: 40365620


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