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Large scale laboratory evolution uncovers clinically relevant collateral antibiotic sensitivity

Author(s): Chowdhury FR; Banari V; Lesnic V; Zhanel GG; Findlay BL;

The increasing prevalence of antibiotic resistance is a critical challenge, necessitating the development of strategies to mitigate the evolution of resistance. Collateral sensitivity (CS)-based sequential therapies have been proposed to mitigate resistance evolution. However, the evolutionary repeatability of CS across different experimental conditions a ...

Article GUID: 40615056


Electro-washing of pipelines spills: On-site strategies for different soil matrices

Author(s): Rajaei E; Elektorowicz M;

Crude oil remains a dominant global energy source but spills from pipelines, and reservoirs pose significant environmental and health risks. Remediating petroleum hydrocarbon (PHC)-contaminated soils is critical yet challenging, especially in fine-grained matrices where conventional methods underperform. In this context, electro-washing (EW), either in-si ...

Article GUID: 40614426


Stability of Acetals/Ketals Under Controlled Radical and Ring Opening Polymerization

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Oh JK;

Well-defined acid-degradable amphiphilic block copolymers (ABPs) and their nanoassemblies labeled with acid-labile groups have been developed for smart drug delivery, exhibiting controlled/enhanced release of therapeutics in tumoral tissues and endo/lysosomes. In general, controlled polymerization techniques, particularly atom transfer radical polymerizat ...

Article GUID: 40614241


Enhanced biodegradation of crude oil by phosphate-solubilizing bacteria Bacillus subtilis PSB-1: Overcoming soluble phosphorus deficiency

Author(s): Wang X; Du Z; Li Z; Liu M; Mu J; Feng L; Chen Z; Chen Q;

Due to the oligotrophic marine environment, the lack of phosphorus is one of the key factors limiting the oil biodegradation ability of microorganisms after the oil spill occurs. Overcoming phosphorus deficiency has become an urgent problem. In this study, a phosphate-solubilizing bacteria, named Bacillus subtilis PSB-1, with the crude oil degradation eff ...

Article GUID: 40609441


Application of machine learning for predicting the incubation period of water droplet erosion in metals

Author(s): AlHammad K; Medraj M; Tembely M;

Water droplet erosion (WDE) is a critical degradation phenomenon that significantly affects component lifespan and performance in power generation, aerospace, and wind energy industries. The incubation period-the initial phase before visible material loss occurs-is particularly crucial for maintenance planning and material selection yet remains challengin ...

Article GUID: 40612685


Personalizing brain stimulation: continual learning for sleep spindle detection

Author(s): Sobral M; Jourde HR; Marjani Bajestani SE; Coffey EBJ; Beltrame G;

Personalized closed-loop brain stimulation, in which algorithms used to detect neural events adapt to a user's unique neural characteristics, may be crucial to enable optimized and consistent stimulation quality for both fundamental research and clinical applications. Precise stimulation of sleep spindles-transient patterns of brain activity that occu ...

Article GUID: 40609549


Production and characterization of magnetic Biochar derived from pyrolysis of waste areca nut husk for removal of methylene blue dye from wastewater

Author(s): Chistie SM; Naik SU; Rajendra P; Apeksha None; Mishra RK; Albasher G; Chinnam S; Jeppu GP; Arif Z; Hameed J;

The textile industry causes lots of pollution due to its discharge of untreated coloured effluents into water bodies, impacting the environment. The present study includes a slow pyrolysis technique to produce magnetic biochar derived from waste areca nut husk (ANH)) biomass to adsorb methylene b ...

Article GUID: 40603323


Characterizing spatiotemporal white matter hyperintensity pathophysiology in vivo to disentangle vascular and neurodegenerative contributions

Author(s): Parent O; Alasmar Z; Osborne S; Bussy A; Costantino M; Fouquet JP; Quesada D; Pastor-Bernier A; Fajardo-Valdez A; Pichet-Binette A; McQuarrie A; Maranzano J; Devenyi GA; Steele CJ; Villeneuve S; ; Dadar M; Chakravarty MM;

White matter hyperintensities (WMHs) are neuroimaging markers widely interpreted as caused by cerebral small vessel disease, yet emerging evidence suggests that a subset may have a neurodegenerative etiology. Current imaging methods have lacked the specificity to disentangle biological processes ...

Article GUID: 40585093


Upconversion Lanthanide-Based 2D Metal-Organic Frameworks for Multimode Information Encryption

Author(s): Chen J; Xie Y; Yang W; Sun R; Xing F; Mandl GA; Capobianco JA; Sun L;

Luminescent 2D metal-organic frameworks (MOFs) are a class of metal-organic framework materials expanded in a 2D plane, which have a wide range of applications in fields of optoelectronic devices, sensors, and information storage due to their unique layered structure and excellent optical properties. Currently, research on luminescent 2D MOFs mainly focus ...

Article GUID: 40557752


Potential value streams of an integrated Canadian serosurveillance network

Author(s): Campbell JR; Russell WA; Wagner CE; Manuel DG; Anipindi V; Baral P; Evans TG; Hankins CA; Sander B;

The Government of Canada, through the COVID-19 Immunity Task Force (CITF), supported over 100 serosurveillance studies during the COVID-19 pandemic, building and strengthening the technical infrastructure necessary for a national serosurveillance network. The value of such a network extends beyon ...

Article GUID: 40588636


Contextual variations in the effects of social withdrawal, peer exclusion, and friendship on growth curves of depressed affect in late childhood

Author(s): Commisso M; Persram RP; Lopez LS; Bukowski WM;

The moderating roles of friendship and contextual variables on associations between social withdrawal and peer exclusion and growth curves of depressed affect were studied with a three-wave multilevel longitudinal design. Participants were 313 boys and girls aged 10-12 from Canada (n = 139), mostly of European and North African descent, and Colombia (n = ...

Article GUID: 40583455


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