Author(s): Díaz-Muñoz C; Bozzarelli I; Lopera-Maya EA; Belbasis L; Lo Faro V; Camargo Tavares L; Heredia-Fernández F; Di Lorenzo B; Sinha T; Esteban Blanco C; Favé MJ; Awadalla P; Walters RG; Bonfiglio F; Zhernakova A; Sanna S; D' Amato M;

Background: Genetic studies of stool frequency (SF), an indirect proxy for gastrointestinal transit, may reveal therapeutically tractable pathways relevant to IBS and other dysmotility disorders. Objective: To identify genes and mechanisms involved in gut motility, providing a foundation for cli ...

Article GUID: 41558814

Author(s): Seralini GE; Jungers G; Andersen A; Antoniou M; Aschner M; Bacon MH; Bertrand M; Bohn T; Bonfleur ML; Bücking E; Defarge N; Djemil R; Domingo JL; Douzelet J; Fagan J; Fournier T; Garcia JLY; Gil S; Hervé-Gruyer P; Hilbeck A; Hilty L; Hub ...

We propose a new paradigm, as toxicology currently lacks the proper perspective. From the 1950s to the 1970s, at least one-third of all toxicological testing in the United States, including for chemicals and drugs, was misleading scientists, and this worldwide issue persists today. Moreover, petr ...

Article GUID: 41551494

Author(s): Hassø RK; Lindtofte S; Kosik B; Bergdahl A; Larsen S;

Article GUID: 41553522

Author(s): Mebarak M; Maïano C; Mendoza J; Chirullo V; Coneo AMC; Compte EJ; Cruz-Licea V; Góngora VC; Henríquez C; Martínez-Banfi M; Mejía Rodriguez DL; Pescetto I; Selma H; Boothroyd LG; Thornborrow T; Todd J; Swami V;

The Functionality Appreciation Scale (FAS) is increasingly used within diverse national and linguistic contexts, but assessments of its functioning across groups remains limited. To extend knowledge, we examined measurement invariance of the FAS across five Latin American nations (Argentina, Chil ...

Article GUID: 41547175

Author(s): Sui J; Bi H; Yue R; Fu H; Yang A; An C;

Persistent oil contamination along coastlines can be treated by surface washing agents (SWAs), while low-temperature conditions can significantly impact the effectiveness of SWAs in oil removal. This study investigates the oil removal performance of a commercial SWA for oiled shoreline sand in cold-region environments. Batch oil removal tests were conduct ...

Article GUID: 41544565

Author(s): Sanami S; Rezaei A; Tremblay SA; Potvin-Jutras Z; Sabra D; Intzandt B; Gagnon C; Mainville-Berthiaume A; Wright L; Gayda M; Iglesies-Grau J; Nigam A; Bherer L; Gauthier CJ;

Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain ...

Article GUID: 41543005

Author(s): Lopez-Miranda IR; Sim JI; Juneau G; Wilds CJ; Beharry AA;

The DNA repair enzyme O6-Methylguanine DNA Methyltransferase (MGMT) is a major contributor in conferring resistance to alkylating agents such as temozolomide (TMZ) in cancers. The use of MGMT inhibitors can suppress resistance and enhance the efficacy of TMZ. However, current inhibitors are nonselective for cancer cells, and as a result, MGMT is also inhi ...

Article GUID: 41531960

Author(s): Vaillancourt N; Montpetit C; Rosenstein B; Fortin M;

Background: Anxiety, depression, and pain-related fears are highly prevalent among individuals with chronic low back pain (CLBP). While aquatic therapy is a promising treatment modality for CLBP, its effects on psychological factors remain poorly understood. Objective: To compare the effects of aquatic therapy (AT) versus standard care (SC) on psychologi ...

Article GUID: 41527881

Author(s): Andrade-Gagnon B; Casillas-Popova SN; Shamekhi M; Bairagi K; Peslherbe GH; Oh JK;

The development of acidic pH-responsive degradable amphiphilic block copolymers (ABPs) and their nanoassemblies has been extensively explored as a promising platform for tumor-targeting drug delivery and cancer therapy. Despite tremendous advances, most acidic pH-degradable ABP nanoassemblies have been designed with acid-labile groups positioned in a sing ...

Article GUID: 41524627

Author(s): Su Y; Wang Z; Fu H; Yang A; Chen X; An C;

The 2023 wildfires caused serious riks to air quality and public health across various provinces in Canada, particularly during the period from May to June. This study aims to systematically evaluate the impact of the May-June wildfire events on air pollution in Canada using satellite Aerosol Optical Depth (AOD) data, along with the Hybrid Single-Particle ...

Article GUID: 41520990

Author(s): Spiech C; Martínez MG; Lazzari G; Penhune V;

The pleasurable urge to move to music ("groove") has been shown to be greatest for moderately complex musical rhythms. This is thought to occur because temporal predictions from the motor system reinforce our perception of the beat when there is a balance between expectation and surprise. The supplementary motor area (SMA) has been identified as ...

Article GUID: 41511416