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Assessing Strengths and Limitations of Magnetoencephalography Source Imaging With Intracerebral EEG

Author(s): Afnan J; Fratello M; Bonini F; Medina Villalon S; Cai Z; Lina JM; Badier JM; Bartolomei F; Gotman J; Bénar CG; Grova C;

Due to the ill-posed nature of source imaging, EEG/MEG source localization remains challenging, particularly for localizing deep brain activity and resting-state signals with low signal-to-noise ratios. Functional connectivity estimated by EEG/MEG is further affected by source-leakage, a spatia ...

Article GUID: 42417498


Young adult self-harm: The role of victimisation and polygenic risk in a population-based longitudinal study

Author(s): Marzecki F; Ouellet-Morin I; Zavos HMS; Côté S; Tremblay RE; Gouin JP; Orri M; Boivin M; Geoffroy MC;

Background: Victimisation has been associated with self-harm (with or without suicidal intent), but little is known about this association during young adulthood-a distinct developmental period. Further, not all individuals who experience victimisation will later engage in self-harm, suggesting ...

Article GUID: 42416628


VIVIE: Virtually Integrated Ventricular Intervention Environment and its effectiveness as a teaching and learning tool

Author(s): O' Connor PL; Mccombe K; De Ribaupierre S; Eagleson R; Kersten-Oertel M;

Purpose: External ventricular drain (EVD) placement is a fundamental neurosurgical procedure for monitoring and relieving elevated intracranial pressure, yet catheter misplacement remains common, particularly during early training. Virtual reality (VR) simulation offers a scalable approach for procedural education. We present VIVIE, a standalone VR-base ...

Article GUID: 42412377


Sleep Oscillations Across Cortical, Subcortical and Cerebellar Structures in Magnetoencephalography

Author(s): Greenlaw K; Calvel A; Bouhour C; Steele CJ; Coffey EBJ;

Sleep involves widespread changes in neural activity, with distinctive oscillatory patterns emerging across frequency bands and brain regions. Characterising these dynamics is essential for understanding their functional roles in health and their disruption in sleep-related disorders. However, most work on healthy humans has used techniques with limited ...

Article GUID: 42403150


Ecological validity framework and neurodevelopmental disabilities: applications for parent training programmes

Author(s): De Luca P; Chae S; D' Amico M;

Article GUID: 42398973


The balancing act of app creation: Navigating the user-centred design of an industry-developed app for adolescents with menstrual pain

Author(s): Gagnon MM; Brilz AR; Gathaatharan HS; Alberts NM; Gordon JL; Pavelich A; Risling T; Stinson JN;

Menstrual pain affects over half of menstruating adolescents, and there is a desire for accessible, adjunct treatments, such as behavioural health interventions in mobile health (mHealth) formats. To date, no mHealth apps for adolescents with menstrual pain have been designed with youth. Althou ...

Article GUID: 42382091


Body temperature drives azole tolerance in Candida albicans by hindering the autophagic degradation of Erg11

Author(s): Feng Y; Zhen C; Li W; Whiteway M; Fang X; Shen X; Jiang Y; Lu H;

Human body temperature has been shown to limit the antifungal efficacy of azoles; however, the precise mechanisms underlying this limitation remain insufficiently understood. In this study, we observed that short-term exposure (24 h) to human body temperature (37 °C), in contrast to 30 °C, significantly enhances the tolerance of Candida albicans to azol ...

Article GUID: 42361441


Human sex-specific hormone effects on cerebrovascular health in males and females

Author(s): Intzandt B; Potvin-Jutras Z; Gauthier CJ;

Circulating sex hormone levels decrease in aging, influencing cerebrovascular health. Estradiol has been shown to support female vascular and brain health, though its effects across the menopausal transition remain unknown. Similarly, the influence of testosterone and other hormones in females is not clear. In males, testosterone is associated with posi ...

Article GUID: 42361914


Prioritizing treatment targets for youths with disruptive behaviours and callous-unemotional traits: a modified Delphi study

Author(s): Diep J; Chen E; Lui JHL;

Background: Youths with disruptive behaviours (DB) and callous-unemotional (CU) traits experience significant impairments and impose substantial costs on families and society. Treatment outcome studies of current DB treatments highlight the need for tailored treatments. Identifying priority treatment targets that integrate empirical evidence with stakeh ...

Article GUID: 42351288


A Systematic Review and Meta-Analysis of Biological Sex Differences in Sleep Spindles and Slow Wave Activity in Adults With and Without Insomnia

Author(s): Walsh NA; Phillips EM; Páez A; Cross NE; Dang-Vu TT; Perrault AA;

Mounting evidence shows sex-based differences in sleep experiences and outcomes, including the prevalence of insomnia disorder. However, the impact of biological sex on brain oscillations during sleep remains poorly understood, especially in the context of insomnia disorder. This is a notable gap, given that neurophysiological aspects of sleep are assoc ...

Article GUID: 42331757


Ureolytic bacteria for MICP application to iron-rich slag materials for waste stabilization and carbon sequestration

Author(s): Wilcox SM; Mulligan CN; Neculita CM;

Microbial induced carbonate precipitation (MICP) is a novel soil and cement strengthening technique for civil and geotechnical engineering fields. Recently emerging is the use of MICP as a biological remediation strategy to immobilize contaminants, strengthen metalliferous waste, and sequester carbon dioxide from mining activities. MICP has a broad spec ...

Article GUID: 42325307


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