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Multilingualism and cognitive reserve in older adults with, or at risk for, Alzheimer s disease: Evidence from resting-state functional connectivity

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional b ...

Article GUID: 42208339


Keeping an Eye on Looking Measures: Towards More Robust Developmental Methods

Author(s): Sander-Montant A; Fibla L; Killam H; Byers-Heinlein K;

A persistent challenge in experimental developmental psychology is determining which of many possible outcome measures best captures underlying behaviors and processes. In the looking-while-listening paradigm for studying early word comprehension, researchers have developed more than 12 distinct outcome measures, but have limited empirical basis for cho ...

Article GUID: 42206598


Investigating substrate specificity in arogenate versus prephenate dehydratases

Author(s): Clayton EJ; Smith-Uffen M; Tribble TW; Duennwald ML; Kohalmi SE;

Background: Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, re ...

Article GUID: 42204708


Atmospheric aging of tire rubber antioxidants forms complex mixtures that trigger inflammation in human macrophages

Author(s): Peng C; Liggio J; Moussa SG; Tang Y; Johannessen C; Zhang X; Zhang Z; Li L; Harner T; Saini A; Hung H; Wentzell J; Wheeler MJ; Dabek-Zlotorzynska E; Yassine M; Liu Q; Tang M; Friel-Bartlett Z; Abdul-Sater AA;

Antioxidants added to tires to prevent degradation have recently been recognized as emerging environmental contaminants. While their acute aquatic toxicity has raised concern, these compounds are also emitted to the atmosphere and can be associated with particulate matter (PM). On PM they can r ...

Article GUID: 42191547


Bilingual Families Align Their Languages During Naturalistic Interactions: Evidence from Two Bilingual Communities

Author(s): Fibla L; Kosie JE; Tsui RK; Potter CE; Lew-Williams C; Byers-Heinlein K;

Bilingual children learn their languages through rich interactions with caregivers within dynamic family contexts. However, little is known about how families align their two languages to support bilingual acquisition and how this varies across bilingual communities. This study examines language choice alignment across two communities: French-English fa ...

Article GUID: 42193667


Prevalence of Metabolically Healthy Obesity in Canadian Children and Adolescents at Entry to Pediatric Weight Management Clinic and One Year Later: A Secondary Analysis of CANadian Pediatric Weight Management Registry Data

Author(s): Cohen TR; Bains A; Ball GDC; Faustini C; Heidl A; Morrison KM;

Few studies have characterized metabolically healthy (MHO) and unhealthy obesity (MUO) in pediatric populations over time. The objective of this study was to determine the prevalence of MHO in children and adolescents enrolled in a weight management program and examine changes in cardiometabolic indicators over 1 year.Methods: Participants from the CANa ...

Article GUID: 42189064


Practices to Reduce Stigma and Discrimination Towards Older Transitional Housing Clients

Author(s): Canham SL; Richardson LR; Aaenson-Fletcher J; Weldrick R; Walsh CA;

Homelessness remains an enduring social issue, in part, due to the stigmatization of and discrimination toward people experiencing homelessness, known as homeism. Despite extant research on the topic, little is known about how homeism, enacted through stigmatization and discrimination, may occur within transitional housing programs or among older people ...

Article GUID: 42184413


Hand to Mouth: Shifting the Bare-Minimum Accessibility Paradigm in XR Through Crip-Hacking and Crip-Aesthetics

Author(s): Jain P; Bayerlein C;

eXtended Reality (XR) technologies often embed ableist design assumptions, privileging hand-based interaction and vision-centric interfaces that presume a normative able-bodied user. As a result, many disabled people-including those with limited mobility or blindness-are excluded from the outset, with accessibility added only as an afterthought. We crit ...

Article GUID: 42182821


Isatin-pyridine oxime hybrids as potential reactivators of A-242-inhibited acetylcholinesterase

Author(s): Pinto AMV; Bhattacharyya D; da Silva MCJ; Kitagawa DAS; Dos Santos MC; Cavalcante SFA; Islam ST; LaPlante SR; Forgione P; Diz JSF; França TCC;

Three new isatin-pyridine-2-oxime hybrids (AM01-03) were synthesized and experimentally evaluated as reactivators of acetylcholinesterase (AChE) inhibited by a surrogate of the nerve agent A-242, in comparison with their 4-oxime isomers previously reported by our research group. Furthermore, th ...

Article GUID: 42171685


A systematic literature review on IoT application layer protocol testing and future research directions

Author(s): Asgari Araghi M; Khendek F;

With the proliferation and the critical role of Internet of Things (IoT) in various domains, rigorous testing techniques are required for improving their quality. Several review studies have examined IoT topology and analyzed different layers of the IoT architecture. These assessments include synthesis on the application layer protocols, but do not spec ...

Article GUID: 42145937


Does Intranasal Oxytocin Reduce Symptoms of Mental Disorders? A Meta-Analysis of Clinical Trials

Author(s): Bonnieux J; Gumuchian ST; Harboun A; Trespalacios F; Bélisle KA; Haddad A; Quintus-Bosz O; McLellan A; Chester-Trudel L; Garred D; Resendes T; Hazel L; Wong SF; Ellenbogen MA;

Intranasal administration of oxytocin has been shown to enhance social cognition and reduce stress reactivity in healthy individuals, suggesting therapeutic potential for mental disorders. However, clinical trials have produced mixed results. Following a systematic search, data were extracted f ...

Article GUID: 42134427


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