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eRNA Reveals Real-Time Signals of Freshwater Fish Population Biomass and Total Abundance

Author(s): Beaulieu J; Morgado-Gamero WB; Fraser DJ; Cristescu ME; Derry AM;

Biomass and abundance data are critical for ecosystem monitoring and management of fish populations, yet their acquisition represents a growing challenge as anthropogenic pressures intensify the need for monitoring. Environmental DNA (eDNA) has the potential to provide cost-effective biomass and abundance estimations, but its high molecular stability ma ...

Article GUID: 42233738


Stimulus Predictability and Liking Enhance Auditory-Motor Encoding and Memory for Melodies

Author(s): Albury AW; Bianco R; Johnson AP; Penhune VB;

The ability to predict or anticipate musical events contributes to music-related pleasure and memory; however, their contributions to learning to play a melody have been less well-explored. In this study, we investigated how musical predictability and pleasure influenced how nonmusicians learned to play short melodies, as well as post-learning recall. P ...

Article GUID: 42229373


em In silico /em rational investigation of C-terminal arginine-containing white Lupin ( em Lupinus albus /em ) protein-derived peptides as arginase inhibitors

Author(s): Chukwuejim S; Fatoki TH; Aluko RE;

Arginase is a binuclear manganese metalloenzyme that modulates L-arginine availability and downstream metabolic pathways. It was hypothesized that C-terminal arginine-containing peptides generated through simulated gastrointestinal digestion of white lupin (Lupinus albus) proteins would exhibit arginase inhibitory activity. To test this hypothesis, inte ...

Article GUID: 42232067


How effective have Canadian national parks been at preventing landscape fragmentation?

Author(s): Freeman-Cole CE; Jaeger JAG;

While landscape connectivity is an important focus of Canada's conservation goals, Canadian national parks are vulnerable to habitat loss, the breaking-up of habitat patches, and a reduction in their connectivity to surrounding ecosystems. This study measured landscape fragmentation in 43 Canadian national parks and control areas throughout their hi ...

Article GUID: 42228295


The Effect of Aortic Regurgitation on Left Ventricular Flow Dynamics Assessed by 4D-Flow MRI

Author(s): Abdallah W; Darwish A; Garcia J; Kadem L;

Background: Aortic regurgitation (AR) alters normal blood flow patterns in the left ventricle (LV), affecting diastolic filling dynamics, and is commonly quantified by the regurgitant fraction (RF). However, conventional diagnostic methods have notable limitations, prompting growing interest in four-dimensional flow magnetic resonance imaging (4D-flow M ...

Article GUID: 42228301


Importin-β1 functions as a chromatin sensor to position the contractile ring for cytokinesis

Author(s): Brancheriau CR; Larocque K; Schick G; Tountas I; Perlman A; Piekny A;

Cytokinesis, the final step of cell division, relies on ingression of a precisely positioned actomyosin ring. Chromatin-associated Ran-GTP fine-tunes ring position, although the mechanism remains unclear. We hypothesize that depletion of Ran-GTP between segregating chromosomes leads to equatorial enrichment of importins, promoting recruitment of the sca ...

Article GUID: 42225064


Subthalamic segmentations in relation to deep brain stimulation volumes in Parkinson s disease

Author(s): Calvano A; Xiao Y; Steidel K; Loehrer PA; Ruppert-Junck MC; Nimsky C; Timmermann L; Bopp MHA; Pedrosa DJ;

Purpose: Accurate segmentation of the subthalamic nucleus (STN) is paramount for optimising outcomes under deep brain stimulation (DBS) in Parkinson's disease (PD). Clinically available tools like Brainlab Elements (BL-E) enable automated segmentations for surgical planning, yet their spati ...

Article GUID: 42225900


Multilingualism and cognitive reserve in older adults with, or at risk for, Alzheimer s disease: Evidence from resting-state functional connectivity

Author(s): Coulter K; Dash T; Best T; Grant N; Ansaldo AI; Phillips NA;

Speaking more than one language is hypothesized to lead to greater brain resilience in aging and Alzheimer's disease, resulting in a delay in the symptom onset of Alzheimer's disease. While previous research has used structural neuroimaging measures to explore the neural underpinnings of this protective effect, few studies have used functional b ...

Article GUID: 42208339


Keeping an Eye on Looking Measures: Towards More Robust Developmental Methods

Author(s): Sander-Montant A; Fibla L; Killam H; Byers-Heinlein K;

A persistent challenge in experimental developmental psychology is determining which of many possible outcome measures best captures underlying behaviors and processes. In the looking-while-listening paradigm for studying early word comprehension, researchers have developed more than 12 distinct outcome measures, but have limited empirical basis for cho ...

Article GUID: 42206598


Investigating substrate specificity in arogenate versus prephenate dehydratases

Author(s): Clayton EJ; Smith-Uffen M; Tribble TW; Duennwald ML; Kohalmi SE;

Background: Phenylalanine is an essential aromatic amino acid that can only be synthesized de novo by microorganisms and plants. In microorganisms, phenylalanine is synthesized through the prephenate pathway, requiring the activity of a prephenate dehydratase (PDT). In plants, phenylalanine is synthesized instead mostly through the arogenate pathway, re ...

Article GUID: 42204708


Atmospheric aging of tire rubber antioxidants forms complex mixtures that trigger inflammation in human macrophages

Author(s): Peng C; Liggio J; Moussa SG; Tang Y; Johannessen C; Zhang X; Zhang Z; Li L; Harner T; Saini A; Hung H; Wentzell J; Wheeler MJ; Dabek-Zlotorzynska E; Yassine M; Liu Q; Tang M; Friel-Bartlett Z; Abdul-Sater AA;

Antioxidants added to tires to prevent degradation have recently been recognized as emerging environmental contaminants. While their acute aquatic toxicity has raised concern, these compounds are also emitted to the atmosphere and can be associated with particulate matter (PM). On PM they can r ...

Article GUID: 42191547


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